Muscle and neuronal guidepost-like cells facilitate planarian visual system regeneration
- 26 June 2020
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 368 (6498), 1447-+
- https://doi.org/10.1126/science.aba3203
Abstract
Neuronal circuits damaged or lost after injury can be regenerated in some adult organisms, but the mechanisms enabling this process are largely unknown. We used the planarian Schmidtea mediterranea to study visual system regeneration after injury. We identify a rare population of muscle cells tightly associated with photoreceptor axons at stereotyped positions in both uninjured and regenerating animals. Together with a neuronal population, these cells promote de novo assembly of the visual system in diverse injury and eye transplantation contexts. These muscle guidepost-like cells are specified independently of eyes, and their position is defined by an extrinsic array of positional information cues. These findings provide a mechanism, involving adult formation of guidepost-like cells typically observed in embryos, for axon pattern restoration in regeneration.Keywords
Funding Information
- Howard Hughes Medical Institute (Investigator)
- Eleanor Schwartz Charitable Foundation (na)
This publication has 73 references indexed in Scilit:
- Transcriptome Analysis of the Planarian Eye Identifies ovo as a Specific Regulator of Eye RegenerationCell Reports, 2012
- A regulatory program for excretory system regeneration in planariansDevelopment, 2011
- Polarized notum Activation at Wounds Inhibits Wnt Function to Promote Planarian Head RegenerationScience, 2011
- Mechanisms and Molecules of Neuronal Wiring: A PrimerCold Spring Harbor Perspectives in Biology, 2010
- Expression of secreted Wnt pathway components reveals unexpected complexity of the planarian amputation responseDevelopmental Biology, 2010
- Wnt Signaling and the Polarity of the Primary Body AxisCell, 2009
- Transient cell–cell interactions in neural circuit formationNature Reviews Neuroscience, 2009
- Regeneration and maintenance of the planarian midline is regulated by a slit orthologueDevelopmental Biology, 2007
- Tangential Neuronal Migration Controls Axon Guidance: A Role for Neuregulin-1 in Thalamocortical Axon NavigationCell, 2006
- A Role for BMP Heterodimers in Roof Plate-Mediated Repulsion of Commissural AxonsNeuron, 2003