Pulmonary hypertension and myocardial function in infants and children with Down syndrome
- 1 November 2020
- journal article
- review article
- Published by BMJ in Archives of Disease in Childhood
- Vol. 105 (11), 1031-1034
- https://doi.org/10.1136/archdischild-2019-318178
Abstract
Down Syndrome (DS) is the most common chromosomal abnormality of live born babies. Individuals with DS are at increased risk of cardiopulmonary morbidities in the early neonatal period, infancy and childhood that manifest with elevated pulmonary arterial pressures and altered myocardial performance. Pulmonary hypertension (PH) during the early neonatal period remains under-recognised in this population. PH may occur with or without a congenital heart defect in children with DS and is more common than in the general population. Early detection and continued screening of PH throughout infancy and childhood for these at-risk children is crucial for prompt intervention and potential prevention of long-term sequelae on cardiac function. This review summarises the main physiological concepts behind the mechanisms of PH in children with DS and provides a summary of the current available literature on PH and its impact on myocardial performance.Keywords
Funding Information
- Health Research Board (.)
- Education Support Grant, National Children's Centre, Dublin (.)
This publication has 33 references indexed in Scilit:
- Deaths Among Children, Adolescents, and Young Adults with Down SyndromeJournal of Applied Research in Intellectual Disabilities, 2013
- Cardiac and Sympathetic Activation are Reduced in Children with Down Syndrome and Sleep Disordered BreathingSleep, 2012
- Pulmonary Complications of Down Syndrome during ChildhoodThe Journal of Pediatrics, 2010
- Distinct Abnormalities in the Innate Immune System of Children with Down SyndromeThe Journal of Pediatrics, 2010
- The 50th anniversary of the discovery of trisomy 21: The past, present, and future of research and treatment of Down syndromeGenetics in Medicine, 2009
- Patients with Pulmonary Hypertension Related to Congenital Systemic-to-Pulmonary Shunts are Characterized by Inflammation Involving Endothelial Cell Activation and Platelet-mediated InflammationCongenital Heart Disease, 2009
- T Lymphocyte Maturation Is Impaired in Healthy Young Individuals Carrying Trisomy 21 (Down Syndrome)American Journal on Intellectual and Developmental Disabilities, 2009
- Pulmonary Hypertension Affects Left Ventricular Basal Twist: A Novel Use for Speckle‐Tracking ImagingEchocardiography, 2008
- Relative rather than absolute macroglossia in patients with Down syndrome: implications for treatment of obstructive sleep apneaPediatric Radiology, 2008
- Prevalence, Neonatal Characteristics, and First-Year Mortality of Down Syndrome: A National StudyThe Journal of Pediatrics, 2008