Patient-reported outcomes in chronic kidney disease
- 25 November 2020
- journal article
- Published by Non-profit organization Nephrology in Nephrology (Saint-Petersburg)
- Vol. 24 (6), 9-18
- https://doi.org/10.36485/1561-6274-2020-24-6-9-18
Abstract
The review provides a definition of the concept of «patient-reported outcomes (PRO)». The main components of PRO include health-related quality of life (QoL), symptoms assessed by the patient, functional status, satisfaction with treatment. The review presents a description of the most frequently used questionnaires for assessing QoL in patients with chronic kidney disease (CKD). It has been shown that the physical component of QoL decreases in predialysis stages of CKD. As CKD progresses, the Physical Component Summary (PCS) of the SF-36 questionnaire deteriorates, as well as the scale scores of Physical functioning, Pain, General health, and Role limitations caused by Physical problems (RP). Among the CKD-specific QoL scales, a deterioration in the scores of Symptoms/Problems, Burden of Kidney Disease, Effects of kidney disease on daily life is observed. There are no convincing data in the literature in favor of a decrease in psychosocial aspects of QoL in patients with CKD. The review presents the definition of «comprehensive conservative care» proposed by the experts convened at the 2013 KDIGO Controversies Conference on Supportive Care. It has been shown that comprehensive conservative care can be a fairly effective method of choice for elderly patients with Stage 5 CKD. It has been demonstrated that a decrease in PCS is independently associated with CKD progression and an increased risk of death. However, the information on QoL in predialysis CKD is insufficient. The use of different questionnaires for QoL assessment complicates data comparison. Randomized clinical trials are practically absent, which reduces the value of the results obtained.Keywords
This publication has 53 references indexed in Scilit:
- EVALUATION OF QUALITY OF LIFE IN HEMODIALYSIS PATIENTS USING THE KDQOL-SFTM QUESTIONNAIRENephrology (Saint-Petersburg), 2017
- Analysing data from patient-reported outcome and quality of life endpoints for cancer clinical trials: a start in setting international standardsThe Lancet Oncology, 2016
- Patients' needs in hematology: whose perspectives?Haematologica, 2013
- ISOQOL recommends minimum standards for patient-reported outcome measures used in patient-centered outcomes and comparative effectiveness researchQuality of Life Research, 2013
- Cultural adaptation and validation of the “Kidney Disease and Quality of Life - Short Form (KDQOL-SF™) version 1.3” questionnaire in EgyptBMC Nephrology, 2012
- The use of real-time patient-reported outcomes and quality-of-life data in oncology clinical practiceExpert Review of Pharmacoeconomics & Outcomes Research, 2011
- Patient-reported outcomes: A new era in clinical researchPerspectives in Clinical Research, 2011
- Validation of the Kidney Disease Quality of Life-Short Form questionnaire in kidney transplant patientsJournal of Psychosomatic Research, 2006
- The World Health Organization's WHOQOL-BREF quality of life assessment: Psychometric properties and results of the international field trial. A Report from the WHOQOL GroupQuality of Life Research, 2004
- Development of the Kidney Disease Quality of Life (KDQOLTM) InstrumentQuality of Life Research, 1994