ARGONAUT II Study of the In Vitro Activity of Plazomicin against Carbapenemase-Producing Klebsiella pneumoniae
- 21 April 2020
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 64 (5)
- https://doi.org/10.1128/aac.00012-20
Abstract
Plazomicin was tested against 697 recently acquired carbapenem-resistant Klebsiella pneumoniae isolates from the Great Lakes region of the United States. Plazomicin MIC50 and MIC90 values were 0.25 and 1 mg/liter, respectively; 680 isolates (97.6%) were susceptible (MICs of ≤2 mg/liter), 9 (1.3%) intermediate (MICs of 4 mg/liter), and 8 (1.1%) resistant (MICs of >32 mg/liter). Resistance was associated with rmtF-, rmtB-, or armA-encoded 16S rRNA methyltransferases in all except 1 isolate.Keywords
Funding Information
- HHS | NIH | National Institute of Allergy and Infectious Diseases (UM1AI104681, R01AI100560, R01AI063517, R01AI072219)
- HHS | NIH | National Institute of Allergy and Infectious Diseases (U19AI110819)
- HHS | NIH | National Institute of Allergy and Infectious Diseases (R01AI090155)
- U.S. Department of Veterans Affairs (1I01BX001974)
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