Comparison of a Short Versus Long Stokes Shift Near-Infrared Dye During Intraoperative Molecular Imaging
- 9 December 2019
- journal article
- research article
- Published by Springer Science and Business Media LLC in Molecular Imaging & Biology
- Vol. 22 (1), 144-155
- https://doi.org/10.1007/s11307-019-01434-2
Abstract
Intraoperative molecular imaging (IMI) utilizes optical dyes that accumulate within tumors to assist with detection during a cancer operation. IMI can detect disease not visualized preoperatively, as well as positive margins. However, these dyes are limited by autofluorescence, signal reflection, and photon-scatter. We hypothesize that a novel dye with a wide separation between excitation and emission spectra, SS180, would help overcome these obstacles.Keywords
Funding Information
- National Center for Advancing Translational Sciences of the NIH (TL1TR001880)
- National Institutes of Health Biomedical Research Partnership (R01 CA193556)
- National Institutes of Health Biomedical Research Partnership (R01 CA193556)
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