Enhanced Efficacy of Simultaneous PD-1 and PD-L1 Immune Checkpoint Blockade in High-Grade Serous Ovarian Cancer
Open Access
- 5 November 2020
- journal article
- research article
- Published by American Association for Cancer Research (AACR) in Cancer Research
- Vol. 81 (1), 158-173
- https://doi.org/10.1158/0008-5472.can-20-1674
Abstract
This study indicates that increased efficacy of immune therapies in ovarian cancer is driven by state changes of NK and small subsets of CD8 T cells into active and cytotoxic states.Keywords
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Funding Information
- HHS | NIH | National Cancer Institute (K08CA241093)
- HHS | NIH | NIH Office of the Director (DP5OD029637)
- American Association for Cancer Research (2019 AACR-AstraZeneca Ovarian Cancer Research Fellowship (Grant Number 19-40-12-HILL))
- DOD | United States Army | MEDCOM | Congressionally Directed Medical Research Programs (W81XWH-19-1-0123)
- Honorable Tina Brozman Foundation (Rising Star Grant)
- Advanced Medical Research Foundation (N/A)
- Vincent Memorial Hospital Foundation (N/A)
- HHS | NIH | National Cancer Institute (R01CA234018)
- China Scholarship Council (201908610120)
- DOD | United States Army | MEDCOM | Congressionally Directed Medical Research Programs (W81XWH-19-1-0147)
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