In vivo and in vitro biocompatibility study of MnFe2O4 and Cr2Fe6O12 as photosensitizer for photodynamic therapy and drug delivery of anti-cancer drugs
- 29 April 2020
- journal article
- research article
- Published by Informa UK Limited in Drug Development and Industrial Pharmacy
- Vol. 46 (5), 846-851
- https://doi.org/10.1080/03639045.2020.1757698
Abstract
In The present project, a variety of MnFe2O4 (Mn) and Cr2Fe6O12 (Cr)-based nanocarriers (NCs) were synthesized as photosensitizer and NCs for delivery of chemotherapeutic curcumin (CUR) and provide a new structure for Photodynamic Therapy (PDT). For determining efficiency of NCs release study, MTT assay, lethal dose test and hemolysis assay were carried out. The release study showed the release of CUR from NCs was pH-dependent, but, every NCs had its own behavior for releasing the drug. The data acquired from the release study showed the CUR release from Mn can reach to over 90% at acidic media instead of 41% at neutral media. However, the CUR released from Cr were approximately equal as Cr had equal zeta potential at both media. Hemolysis activity and lethal dose test displayed the cytotoxicity of NCs was neglectable at both in vitro and in vivo study. Also, the results of anti-cancer activity assay (MTT assay) showed that both of Cr and Mn NCs are suitable systems for PDT. Therefore, the results demonstrated that Mn is suitable NCs for PDT and anticancer drugs delivery of therapeutic drugs.Keywords
This publication has 34 references indexed in Scilit:
- The role of miktoarm star copolymers in drug delivery systemsJournal of Macromolecular Science, Part A, 2018
- Efficient treatment of breast cancer xenografts with multifunctionalized iron oxide nanoparticles combining magnetic hyperthermia and anti-cancer drug deliveryBreast Cancer Research, 2015
- Photodynamic therapy of cancer: An updateCA: A Cancer Journal for Clinicians, 2011
- Photosensitizer-conjugated magnetic nanoparticles for in vivo simultaneous magnetofluorescent imaging and targeting therapyBiomaterials, 2011
- Liposomes and nanoparticles: nanosized vehicles for drug delivery in cancerTrends in Pharmacological Sciences, 2009
- Therapeutic Nanoparticles for Drug Delivery in CancerClinical Cancer Research, 2008
- Multifunctional Polymeric Micelles as Cancer-Targeted, MRI-Ultrasensitive Drug Delivery SystemsNano Letters, 2006
- Mechanisms in photodynamic therapy: part one—photosensitizers, photochemistry and cellular localizationPhotodiagnosis and Photodynamic Therapy, 2004
- Synthesis of Bacteriochlorins and Their Potential Utility in Photodynamic Therapy (PDT)Current Organic Chemistry, 2004
- Liposome-based drug delivery in breast cancer treatmentBreast Cancer Research, 2002