Adipokines, Cardiovascular Risk, and Therapeutic Management in Obesity and Psoriatic Arthritis
Open Access
- 10 February 2021
- journal article
- review article
- Published by Frontiers Media SA in Frontiers in Immunology
Abstract
Psoriatic arthritis is a chronic inflammatory disease with skin and joint pathology as the dominant characteristics. Scientific evidence supports its systemic nature and relevant relationship with obesity, metabolic syndrome, and associated conditions. Metabolic syndrome and obesity share common signaling pathways with joint inflammation, reinforcing the idea that adipose tissue is a major contributor to disease development and severity. The adipose tissue is not a mere energy store but also an endocrine organ participating in the immune response. In the search for the best therapeutic strategy for a patient, we should appraise the adipose tissue as an endocrine and immune organ responsible for mild chronic inflammation. Today, our challenge is not only to achieve disease remission but to control the associated comorbidities as well. In light of the high prevalence of obesity in psoriatic arthritis patients and the importance of the adipose tissue in the development of chronic inflammation, we aimed to identify the most relevant articles in this regard published in English until June 2020 using the PubMed database. Search terms included psoriatic arthritis, in combination with metabolic syndrome, obesity, adipokines, cardiovascular disease, and treatment. This review summarizes the current evidence regarding the role of adipose tissue as an adipokine-secreting endocrine organ, discussing its influence on disease development and severity, and ultimately in meeting successful disease management.Keywords
This publication has 109 references indexed in Scilit:
- Metabolic disturbances and worsening of atherosclerotic lesions in ApoE-/- mice after cola beverages drinkingCardiovascular Diabetology, 2013
- Serum level of adiponectin is a surrogate independent biomarker of radiographic disease progression in early rheumatoid arthritis: results from the ESPOIR cohortArthritis Research & Therapy, 2013
- Adipokines in Psoriatic Arthritis Patients: The Correlations with Osteoclast Precursors and Bone ErosionsPLOS ONE, 2012
- Markers of inflammation and bone remodelling associated with improvement in clinical response measures in psoriatic arthritis patients treated with golimumabAnnals Of The Rheumatic Diseases, 2012
- Adipogenesis: From Stem Cell to AdipocyteAnnual Review of Biochemistry, 2012
- Cardiovascular Risk in Patients with Psoriatic ArthritisInternational Journal of Rheumatology, 2012
- Association of circulating adiponectin levels with progression of radiographic joint destruction in rheumatoid arthritisAnnals Of The Rheumatic Diseases, 2011
- Trends in incidence of adult-onset psoriasis over three decades: A population-based studyJournal of the American Academy of Dermatology, 2009
- Increased prevalence of the metabolic syndrome in patients with moderate to severe psoriasisArchiv für dermatologische Forschung, 2006
- Adipocytokines: mediators linking adipose tissue, inflammation and immunityNature Reviews Immunology, 2006