One-Fifth of Children with Sickle Cell Anemia Show Exercise-Induced Hemoglobin Desaturation: Rate of Perceived Exertion and Role of Blood Rheology
Open Access
- 2 January 2020
- journal article
- research article
- Published by MDPI AG in Journal of Clinical Medicine
- Vol. 9 (1), 133
- https://doi.org/10.3390/jcm9010133
Abstract
Perceived exertion is an important self-limiting factor influencing functional capacity in patients with sickle cell anemia (SCA). Exercise-related hemoglobin desaturation (EHD) may occur during a six-minute walking test (6MWT) and could influence the perceived rate of exertion. The aims of this study were (1) to compare the 6MWT responses (heart rate, perceived rate of exertion, and distance covered) between SCA children with and without EHD, and (2) to test the associations between EHD and several biological/physiological parameters. Nine of 51 SCA children (18%) at steady state (mean age 11.9 ± 3.8 years) exhibited EHD at the end of the 6MWT. The rate of perceived exertion increased with exercise in the two groups, but reached higher values in the EHD group. Heart rate and performance during the 6MWT did not differ between the two groups. The magnitude of change in SpO2 during the 6MWT was independently associated with the red blood cell (RBC) deformability and RBC aggregates strength. This study demonstrates that SCA children with EHD during a 6MWT have a higher rate of perceived exertion than non-EHD children despite a similar physiological demand, and that abnormal RBC rheology determinants appear to be significant contributors.Keywords
Funding Information
- labex GR-Ex (GR14/ParisDiderot/02)
This publication has 32 references indexed in Scilit:
- Hematologic and hemorheological determinants of resting and exercise-induced hemoglobin oxygen desaturation in children with sickle cell diseaseHaematologica, 2013
- Hemorheological risk factors of acute chest syndrome and painful vaso-occlusive crisis in children with sickle cell diseaseHaematologica, 2012
- Prospective evaluation of haemoglobin oxygen saturation at rest and after exercise in paediatric sickle cell disease patientsBritish Journal of Haematology, 2009
- Red blood cell aggregation, aggregate strength and oxygen transport potential of blood are abnormal in both homozygous sickle cell anemia and sickle-hemoglobin C diseaseHaematologica, 2009
- Elevated tricuspid regurgitant jet velocity in children and adolescents with sickle cell disease: association with hemolysis and hemoglobin oxygen desaturationHaematologica, 2009
- Effects of erythrocyte flexibility on microvascular perfusion and oxygenation during acute anemiaAmerican Journal of Physiology-Heart and Circulatory Physiology, 2007
- Hemodynamic and Functional Assessment of Patients with Sickle Cell Disease and Pulmonary HypertensionAmerican Journal of Respiratory and Critical Care Medicine, 2007
- Interpretative strategies for lung function testsEuropean Respiratory Journal, 2005
- Is Hemoglobin Desaturation Related to Blood Viscosity in Athletes During Exercise?International Journal of Sports Medicine, 2004
- Exercise-Induced Arterial Hypoxaemia in AthletesSports Medicine, 2000