Mouse Models ofc-mycDeregulation Driven by IgH Locus Enhancers as Models of B-Cell Lymphomagenesis
Open Access
- 23 July 2020
- journal article
- review article
- Published by Frontiers Media SA in Frontiers in Immunology
- Vol. 11, 1564
- https://doi.org/10.3389/fimmu.2020.01564
Abstract
Chromosomal translocations linking various oncogenes to transcriptional enhancers of the immunoglobulin heavy chain (IgH) locus are often implicated as the cause of B-cell malignancies. Two major IgH transcriptional enhancers have been reported so far. The E(mu)enhancer located upstream of the C(mu)gene controls early events in B-cell maturation such as VDJ recombination. The 3' regulatory region (3'RR) located downstream from the C(alpha)gene controls late events in B-cell maturation such as IgH transcription, somatic hypermutation, and class switch recombination. Convincing demonstrations of the essential contributions of both E(mu)and 3'RR in B-cell lymphomagenesis have been provided by transgenic and knock-in animal models which bring the oncogenec-mycunder E-mu/3'RR transcriptional control. This short review summarizes the different mouse models so far available and their interests/limitations for progress in our understanding of humanc-myc-induced B-cell lymphomagenesis.Keywords
Funding Information
- Agence Nationale de la Recherche
- Ligue Contre le Cancer
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