An epidermal patch for the simultaneous monitoring of haemodynamic and metabolic biomarkers
Top Cited Papers
- 15 February 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature Biomedical Engineering
- Vol. 5 (7), 737-748
- https://doi.org/10.1038/s41551-021-00685-1
Abstract
Monitoring the effects of daily activities on the physiological responses of the body calls for wearable devices that can simultaneously track metabolic and haemodynamic parameters. Here we describe a non-invasive skin-worn device for the simultaneous monitoring of blood pressure and heart rate via ultrasonic transducers and of multiple biomarkers via electrochemical sensors. We optimized the integrated device so that it provides mechanical resiliency and flexibility while conforming to curved skin surfaces, and to ensure reliable sensing of glucose in interstitial fluid and of lactate, caffeine and alcohol in sweat, without crosstalk between the individual sensors. In human volunteers, the device captured physiological effects of food intake and exercise, in particular the production of glucose after food digestion, the consumption of glucose via glycolysis, and increases in blood pressure and heart rate compensating for oxygen depletion and lactate generation. Continuous and simultaneous acoustic and electrochemical sensing via integrated wearable devices should enrich the understanding of the body’s response to daily activities, and could facilitate the early prediction of abnormal physiological changes.Keywords
Funding Information
- Ministry of Science, Technology and Innovation | Conselho Nacional de Desenvolvimento Científico e Tecnológico (216981/2014-0)
- University of California Institute for Mexico and the United States (2017-2022)
- Thailand Research Fund
- Fulbright Egyptian Scholar Program
- Foundation for the National Institutes of Health (1R21EB027303-01A1)
- UCSD Center of Wearable Sensors
This publication has 57 references indexed in Scilit:
- Epidermal Biofuel Cells: Energy Harvesting from Human PerspirationAngewandte Chemie-International Edition, 2013
- Diabetes and Hypertension: Is There a Common Metabolic Pathway?Current Atherosclerosis Reports, 2012
- Non-invasive estimate of blood glucose and blood pressure from a photoplethysmograph by means of machine learning techniquesArtificial Intelligence in Medicine, 2011
- Influence of acute alcohol ingestion on sympathetic neural responses to orthostatic stress in humansAmerican Journal of Physiology-Endocrinology and Metabolism, 2011
- NHERF1 and NHERF2 are necessary for multiple but usually separate aspects of basal and acute regulation of NHE3 activityAmerican Journal of Physiology-Cell Physiology, 2011
- Effects of Habitual Alcohol Intake on Ambulatory Blood Pressure, Heart Rate, and Its Variability Among Japanese MenHypertension, 2009
- Alcohol Intake and Blood Pressure: A Systematic Review Implementing a Mendelian Randomization ApproachPLoS Medicine, 2008
- Severe hypotension and hypothermia caused by acute ethanol toxicityEmergency Medicine Journal, 2007
- Potential causes, mechanisms, and implications of post exercise hypotensionJournal of Human Hypertension, 2002
- Diabetes mellitus and hypertension.Hypertension, 1992