The economic burden of Clostridioides difficile infection in patients with hematological malignancies in the United States: A case-control study
- 1 July 2020
- journal article
- research article
- Published by Cambridge University Press (CUP) in Infection Control & Hospital Epidemiology
- Vol. 41 (7), 813-819
- https://doi.org/10.1017/ice.2020.153
Abstract
Objective: The primary study aim was to describe all direct healthcare costs associated with Clostridioides difficile infection (CDI), both in and out of the hospital, in patients with hematologic malignancies in the United States. Design: A retrospective analysis was conducted utilizing data from US databases of Truven Health Analytics. Patients: We analyzed health insurance claims between January 2014 and December 2017 of patients diagnosed with hematological cancer: acute myeloid leukemia (AML), acute lymphoblastic leukemia, Hodgkin's lymphoma, and non-Hodgkin's lymphoma (NHL). Methods: Patients with CDI after cancer diagnosis (CDI+, cases) were matched with patients without CDI reported (CDI-, controls). Matched cases and controls were compared to identify the CDI-associated costs in the 90 days following the onset of CDI. Results: We matched 622 CDI+ patients with 11,111 CDI- patients. NHL (41.7%) and AML (30.9%) were the predominant underlying diseases in the CDI+ groups. During study period, the average time in-hospital of CDI+ patients was 23.1 days longer than for CDI- patients (P < 2x10(-16)). Overall, CDI onset increased costs of care by an average of US$57,159 per patient (P = 6x10(-12)), mainly driven by hospital costs. Conclusions: This study confirms the significant economic burden associated with CDI in the United States, especially in patients with hematological malignancies. These findings highlight the need for prevention of CDI in this specific patient population.This publication has 21 references indexed in Scilit:
- Epidemiological and economic burden of Clostridium difficile in the United States: estimates from a modeling approachBMC Infectious Diseases, 2016
- Clostridium difficile Infections amongst Patients with Haematological Malignancies: A Data Linkage StudyPLOS ONE, 2016
- Economic burden of Clostridium difficile associated diarrhoea: a cost-of-illness study from a German tertiary care hospitalInfection, 2015
- Ökonomische Auswirkungen einer Clostridium-difficile-Enterokolitis in deutschen Krankenhäusern auf der Basis von DRG-KostendatenZeitschrift für Gastroenterologie, 2015
- Outcomes of Clostridium difficile Infection in Hospitalized Leukemia Patients: A Nationwide AnalysisInfection Control & Hospital Epidemiology, 2015
- Clostridium Difficile Colonization and Disease in Patients Undergoing Hematopoietic Stem Cell TransplantationTransplantation and Cellular Therapy, 2014
- PIN13 The Incremental Economic Burden of Clostridium-Difficile Associated Diarrhea Among Hospitalized Patients at High Risk of Recurrent InfectionValue in Health, 2012
- Clostridium difficile-associated diarrhoea, a frequent complication in patients with acute myeloid leukaemiaAnnals of Hematology, 2009
- Clinical Recognition and Diagnosis ofClostridium difficileInfectionClinical Infectious Diseases, 2008
- Accuracy of ICD-9 coding for Clostridium difficile infections: a retrospective cohortEpidemiology and Infection, 2006