PROMIS-29 survey confirms major impact of fatigue on health-related quality of life in common variable immunodeficiency
- 1 December 2020
- journal article
- research article
- Published by Springer Science and Business Media LLC in Immunologic Research
- Vol. 68 (6), 379-388
- https://doi.org/10.1007/s12026-020-09162-4
Abstract
Health-related quality of life (HRQOL) is an emerging topic of interest in patients with immunodeficiency. Information about HRQOL in common variable immunodeficiency (CVID) is limited. The primary objective was to compare primary immunodeficiency disease (PIDD) patients with and without common variable immunodeficiency (CVID) on HRQOL domains using Patient-Reported Outcomes Measurement Information System (PROMIS-29) survey data from the United States Immunodeficiency Network (USIDNET) registry. The primary endpoint variables were scores on 7 HRQOL domains. The USIDNET registry was used to select patients with baseline PROMIS-29 data collected between 2015 and 2018. Descriptive statistics, Fisher's exact test, and Student's two-sample t test were used to compare patients with CVID versus patients with non-CVID on demographic and clinical characteristics. The single-sample t test was used to compare sample means to the normed population mean of 50. A general linear model approach to multiple regression with backward selection was used to remove factors that did not contribute significant information to the multivariable models, while controlling for multiple testing. Potential explanatory variables included group (CVID/non-CVID), sex, age, and BMI. Among 184 PIDD patients, 146 (79%) were diagnosed with CVID. Patients had a mean (SD) age of 53 (13.8), were predominantly female (83%), and were Caucasian (98%). PROMIS-29 results revealed a significant effect of group (CVID/non-CVID) on the anxiety, fatigue, and social participation domains, with fatigue being the most statistically significant. Fatigue, anxiety, and social participation may be key factors influencing HRQOL among patients with CVID. Future prospective longitudinal studies using PROMIS-29 will be needed to confirm these findings and to determine the mechanisms through which these factors develop in CVID, and how they can be improved.Keywords
This publication has 34 references indexed in Scilit:
- Health-related quality of life in patients with primary immunodeficiency diseaseAllergy, Asthma & Clinical Immunology, 2015
- Longitudinal Study on Health-Related Quality of Life in a Cohort of 96 Patients with Common Variable Immune DeficienciesFrontiers in Immunology, 2014
- Current treatment options with immunoglobulin G for the individualization of care in patients with primary immunodeficiency diseaseClinical and Experimental Immunology, 2014
- Quality of Life in Children with Primary Antibody DeficiencyJournal of Clinical Immunology, 2014
- Health Related Quality of Life and Emotional Health in Children with Chronic Granulomatous Disease: A Comparison of Those Managed Conservatively with Those That Have Undergone Haematopoietic Stem Cell TransplantJournal of Clinical Immunology, 2012
- Health Related Quality of Life in Common Variable ImmunodeficiencyYonsei Medical Journal, 2012
- Treatment of immunodeficiency: Long-term outcome and quality of lifeJournal of Allergy and Clinical Immunology, 2008
- The Quality of Life of Children and Adolescents with X-Linked AgammaglobulinemiaJournal of Clinical Immunology, 2008
- Selective IgA deficiency (SIgAD) and common variable immunodeficiency (CVID)Clinical and Experimental Immunology, 2000
- Common Variable Immunodeficiency: Clinical and Immunological Features of 248 PatientsClinical Immunology, 1999