Endogenous Mobilization of Mesenchymal Stromal Cells: A Pathway for Interorgan Communication?
Open Access
- 8 January 2021
- journal article
- review article
- Published by Frontiers Media SA in Frontiers in Cell and Developmental Biology
Abstract
To coordinate specialized organs, inter-tissue communication appeared during evolution. Consequently individual organs communicate their states via a vast interorgan communication network (ICN) made up of peptides, proteins and metabolites that act between organs to coordinate cellular processes under homeostasis and stress. However, the nature of the interorgan signalling could be even more complex and involve mobilization mechanisms of unconventional cells that are still poorly described. Mesenchymal stem/stromal cells (MSCs) virtually reside in all tissues though the biggest reservoir discovered so far is adipose tissue where they are named adipose stromal cells (ASCs). MSCs are thought to participate to tissue maintenance and repair since the administration of exogenous MSCs is well known to exert beneficial effects under several pathological conditions. However, the role of endogenous MSCs is barely understood. Though largely debated, the presence of circulating endogenous MSCs has been reported in multiple pathophysiological conditions but the significance of such cell circulation is not known and therapeutically untapped. In this review we discuss current knowledge on the circulation of native MSCs and we highlight recent findings describing MSCs as putative key components of the ICN.Keywords
Funding Information
- Institut National de la Santé et de la Recherche Médicale
- Centre National de la Recherche Scientifique
- AFM-Téléthon
- Fondation pour la Recherche Médicale
This publication has 96 references indexed in Scilit:
- Mesenchymal stem cells are mobilized from the bone marrow during inflammationFrontiers in Immunology, 2013
- Mobilization of bone marrow mesenchymal stem cells in vivo augments bone healing in a mouse model of segmental bone defectBone, 2012
- Targeting stem cell niches and trafficking for cardiovascular therapyPharmacology & Therapeutics, 2011
- Native human adipose stromal cells: localization, morphology and phenotypeInternational Journal of Obesity, 2011
- Membrane vesicles as conveyors of immune responsesNature Reviews Immunology, 2009
- Highly Efficient Drug Delivery with Gold Nanoparticle Vectors for in Vivo Photodynamic Therapy of CancerJournal of the American Chemical Society, 2008
- Bone marrow–derived circulating progenitor cells fail to transdifferentiate into adipocytes in adult adipose tissues in miceJCI Insight, 2007
- Immunosurveillance by Hematopoietic Progenitor Cells Trafficking through Blood, Lymph, and Peripheral TissuesCell, 2007
- Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statementCytotherapy, 2006
- Multilineage Cells from Human Adipose Tissue: Implications for Cell-Based TherapiesTissue Engineering, 2001