Plasma proteomic profiles differ between European and North American myotid bats colonized by Pseudogymnoascus destructans
Open Access
- 12 April 2020
- journal article
- research article
- Published by Wiley in Molecular Ecology
- Vol. 29 (9), 1745-1755
- https://doi.org/10.1111/mec.15437
Abstract
Emerging fungal diseases have become challenges for wildlife health and conservation. North American hibernating bat species are threatened by the psychrophilic fungus Pseudogymnoascus destructans (Pd) causing the disease called white‐nose syndrome (WNS) with unprecedented mortality rates. The fungus is widespread in North America and Europe, however, disease is not manifested in European bats. Differences in epidemiology and pathology indicate an evolution of resistance or tolerance mechanisms towards Pd in European bats. We compared the proteomic profile of blood plasma in healthy and Pd‐colonized European Myotis myotis and North American Myotis lucifugus in order to identify patho‐physiological changes associated with Pd colonization, which might also explain the differences in bat survival. Expression analyses of plasma proteins revealed differences in healthy and Pd‐colonized M. lucifugus, but not in M. myotis. We identified differentially expressed proteins for acute phase response, constitutive and adaptive immunity, oxidative stress defense, metabolism and structural proteins of exosomes and desmosomes, suggesting a systemic response against Pd in North American M. lucifugus but not European M. myotis. The differences in plasma proteomic profiles between European and North American bat species colonized by Pd suggest European bats have evolved tolerance mechanisms towards Pd infection.Keywords
This publication has 82 references indexed in Scilit:
- Handling Stress and Sample Storage Are Associated with Weaker Complement-Mediated Bactericidal Ability in Birds but Not BatsPhysiological and Biochemical Zoology, 2018
- Proteomics in Veterinary Medicine and Animal Science: Neglected Scientific Opportunities with Immediate ImpactProteomics, 2018
- Alterations in the health of hibernating bats under pathogen pressureScientific Reports, 2018
- History and recent progress on chytridiomycosis in amphibiansFungal Ecology, 2016
- Pseudogymnoascus destructans: Evidence of Virulent Skin Invasion for Bats Under Natural Conditions, EuropeTransboundary and Emerging Diseases, 2014
- Molecular signatures mostly associated with NK cells are predictive of relapse free survival in breast cancer patientsJournal of Translational Medicine, 2013
- Hibernation: the immune system at rest?Journal of Leukocyte Biology, 2010
- Bat White-Nose Syndrome: An Emerging Fungal Pathogen?Science, 2009
- Emerging infectious diseases of plants: pathogen pollution, climate change and agrotechnology driversTrends in Ecology & Evolution, 2004
- The Human Plasma ProteomeMolecular & Cellular Proteomics, 2004