The Structural Properties of Odorants Modulate Their Association to Human Odorant Binding Protein
Open Access
- 21 January 2021
- journal article
- research article
- Published by MDPI AG in Biomolecules
- Vol. 11 (2), 145
- https://doi.org/10.3390/biom11020145
Abstract
The binding of known odorant molecules to the human odorant-binding protein (hOBP) was evaluated in silico. Docking experiments elucidate the preferable binding site and binding affinity of odorant molecules to hOBP. The physicochemical properties molecular weight (MW), vapor pressure (Vp), hydrophobicity level (logP), number of double bonds (NºDB), degree of unsaturation (DoU) and the chemical classification, were selected for the study of odorant modulation. Here, these properties were analyzed concerning 30 pleasant and 30 unpleasant odorants, chosen to represent a wide variety of compounds and to determine their influence on the binding energy to hOBP. Our findings indicate that MW, logP and Vp are the most important odorant variables, directly correlated to odorant-binding energies (Gbinding) towards hOBP. Understanding how the odorants behave when complexed with the OBP in human olfaction opens new possibilities for the development of future biotechnological applications, including sensory devices, medical diagnosis, among others.
Keywords
Funding Information
- Fundação para a Ciência e a Tecnologia (UID/BIO/04469/2019)
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