Full characterisation of knee extensors’ function in ageing: effect of sex and obesity
- 1 February 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in International Journal of Obesity
- Vol. 45 (4), 895-905
- https://doi.org/10.1038/s41366-021-00755-z
Abstract
Background/Objectives Muscle function is a marker of current and prospective health/independence throughout life. The effects of sex and obesity (OB) on the loss of muscle function in ageing remain unresolved, with important implications for the diagnosis/monitoring of sarcopenia. To characterise in vivo knee extensors’ function, we compared muscles torque and power with isometric and isokinetic tests in older men (M) and women (W), with normal range (NW) of body mass index (BMI) and OB. Subjects/Methods In 70 sedentary older M and W (69 ± 5 years), NW and OB (i.e. BMI < 30 kg m−2 and ≥30 kg m−2, respectively) we tested the right knee’s extensor: (i) isometric torque at 30°, 60°, 75° and 90° knee angles, and (ii) isokinetic concentric torque at 60, 90, 150, 180 and 210° s−1 angular speeds. Maximal isometric T–angle, maximal isokinetic knee-extensor torque–velocity, theoretical maximal shortening velocity, maximal power, optimal torque and velocity were determined in absolute units, normalised by body mass (BM) and right leg lean mass (LLMR) and compared over sex, BMI categories and angle or angular speeds by three-way ANOVA. Results In absolute units, relative to BM and LLMR, sex differences were found in favour of M for all parameters of muscle function (main effect for sex, p < 0.05). OB did not affect either absolute or relative to LLMR isometric and isokinetic muscle function (main effect for BMI, p > 0.05); however, muscle function indices, when adjusted for BM, were lower in both M and W with OB compared to NW counterparts (p < 0.05). Conclusions We confirmed sex differences in absolute, relative to BM and LLMR muscle function in favour of men. While overall muscle function and muscle contractile quality is conserved in individuals with class I OB, muscle function normalised for BM, which defines the ability to perform independently and safely the activities of daily living, is impaired in comparison with physiological ageing.Keywords
This publication has 57 references indexed in Scilit:
- Toward a sex‐specific relationship between muscle strength and appendicular lean body mass index?Journal of Cachexia, Sarcopenia and Muscle, 2013
- Sarcopenia as a risk factor for falls in elderly individuals: Results from the ilSIRENTE studyClinical Nutrition, 2012
- Obesity and use of compensatory strategies to perform common daily activities in pre-clinically disabled older adultsArchives of Gerontology and Geriatrics, 2011
- Validity of the international physical activity questionnaire short form (IPAQ-SF): A systematic reviewInternational Journal of Behavioral Nutrition and Physical Activity, 2011
- Longitudinal study of muscle strength, quality, and adipose tissue infiltrationThe American Journal of Clinical Nutrition, 2009
- Physical disability and muscular strength in relation to obesity and different body composition indexes in a sample of healthy elderly womenInternational Journal of Obesity, 2004
- Strength and power changes of the human plantar flexors and knee extensors in response to resistance training in old ageActa Physiologica Scandinavica, 2002
- Research design and statistics in biomechanics and motor controlJournal of Sports Sciences, 2001
- Abduction-adduction moments at the knee during stair ascent and descentJournal of Biomechanics, 1996
- Speed variation and resultant joint torques during sit-to-standArchives Of Physical Medicine and Rehabilitation, 1991