Independent and interactive effect of sitting time and physical activity on prevalence of hyperuricemia: the Henan Rural Cohort Study
Open Access
- 6 January 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in Arthritis Research & Therapy
- Vol. 23 (1), 1-10
- https://doi.org/10.1186/s13075-020-02385-8
Abstract
There are few studies on the hyperuricemia (HUA) and moderate to vigorous intensity physical activity (PA) and also hardly regarding sitting time (ST). The purpose of this study was to examine the independent and interactive association of PA and ST with HUA. A cross-sectional analysis was performed on 38,855 participants (aged 18–79) enrolled from the Henan Rural Cohort Study at baseline (2015 to 2017). PA and ST levels were assessed by using the International Physical Activity Questionnaire (IPAQ). HUA was defined as a serum uric acid level of > 7.0 mg/dL for males and > 6.0 mg/dL for females. Multivariable logistic regression and linear regression models were applied to examine the independent association between PA or ST and HUA and serum uric acid level. Interaction plots were used to visualize the interaction effects of PA and ST on HUA. PA level was inversely related with serum uric acid level (β − 0.15, 95% confidence interval (CI) − 0.22, − 0.07), but ST was positively related with uric acid level (β 2.12, 95% CI 1.90, 2.34). Metabolic equivalent (MET-hour/day) was associated with decreased prevalence of HUA (odds ratio (OR) 0.97, 95% CI 0.96, 0.99), while per hour increased for ST was associated with increased HUA (OR 1.05, 95% CI 1.04, 1.06). The interaction of PA and ST was significant (P < 0.001). Exposure to higher ST was independently related to increased prevalence of HUA, while vigorous PA with a decreased HUA prevalence. Meanwhile, higher daily ST might attenuate the protective effect of PA on HUA. The Henan Rural Cohort Study has been registered at Chinese Clinical Trial Register (Registration number: ChiCTR-OOC-15006699).Keywords
Other Versions
Funding Information
- Foundation of National Key Program of Research and Development of China (2016YFC0900803)
- National Natural Science Foundation of China (81573243, 81602925)
- Henan Provincial Science Fund for Distinguished Young Scholars (164100510021)
- Science and Technology Innovation Talents Support Plan of Henan Province Colleges and Universities (14HASTIT035)
This publication has 32 references indexed in Scilit:
- The prevalence and correlates of sitting in European adults - a comparison of 32 Eurobarometer-participating countriesInternational Journal of Behavioral Nutrition and Physical Activity, 2013
- Relationship between lifestyle choices and hyperuricemia in Chinese men and womenClinical Rheumatology, 2012
- Amount of time spent in sedentary behaviors and cause-specific mortality in US adultsThe American Journal of Clinical Nutrition, 2012
- Dose Response Between Physical Activity and Risk of Coronary Heart DiseaseCell Metabolism, 2011
- Prevalence of gout and hyperuricemia in the US general population: The National Health and Nutrition Examination Survey 2007-2008Arthritis & Rheumatism, 2011
- Too Much SittingExercise and Sport Sciences Reviews, 2010
- Hyperuricemia as an Independent Risk Factor of Chronic Kidney Disease in Middle-Aged and Elderly PopulationThe American Journal of the Medical Sciences, 2010
- Physical Activity and Television Watching in Relation to Risk of Type 2 Diabetes: The Black Women's Health StudyAmerican Journal of Epidemiology, 2008
- High Serum Uric Acid as a Novel Risk Factor for Type 2 DiabetesDiabetes Care, 2008
- Role of Low Energy Expenditure and Sitting in Obesity, Metabolic Syndrome, Type 2 Diabetes, and Cardiovascular DiseaseDiabetes, 2007