Olive Leaf Powder Modulate Insulin Production and Circulating Adipokines in Streptozotocin Induced Diabetic Rats
- 11 June 2021
- journal article
- research article
- Published by Informa UK Limited in Journal of Dietary Supplements
- Vol. 19 (4), 1-16
- https://doi.org/10.1080/19390211.2021.1914267
Abstract
Olives (Olea europaea) have natural phytochemical compounds that are of great importance for their potential beneficially health effects. This study aimed to evaluate the effects of olive leaf powder (OLP) on insulin production and circulating adipokines in streptozotocin-induced diabetic rats. Forty Wistar-albino male rats, weighing 200–225 g were divided into four groups (n = 10); group I: Normal healthy rats received balanced diet; group II: Diabetic control rats receiving balanced diet; group III: Diabetic rats receiving balanced diet + standard antidiabetic drugs (metformin, 600 mg/bw) and group four: Diabetic rats received diet supplemented with 2.0% OLP. The experiment was conducted for four weeks. Our results showed that the consumption of 2.0% OLP decreased serum glucose, triglycerides (TG), total cholesterol (TC), and low-density lipoprotein (LDL) levels, whereas serum high density lipoprotein (HDL) level was increased. OLP supplementation also inhibited the atherogenic index [AI; log (TG/HDL-C) and atherogenic coefficient (AC)] levels relative to those of the untreated diabetic group. Moreover, OLP increased serum adiponectin concentration, and decreased serum leptin concentration. Liver and kidney functions were also attenuated by OLP. This finding also implies that OLP can play an important role in the treatment and delay of diabetic complications.Keywords
This publication has 65 references indexed in Scilit:
- Effect of Olea europaea leaves extract on streptozotocin induced diabetes in male albino ratsSaudi Journal of Biological Sciences, 2017
- Comparison of type 2 diabetes prevalence estimates in Saudi Arabia from a validated Markov model against the International Diabetes Federation and other modelling studiesDiabetes Research and Clinical Practice, 2014
- Hypoglycemic, hypolipidemic and antiatherogenic effects of oleuropein in alloxan-induced Type 1 diabetic ratsAsian Pacific Journal of Tropical Disease, 2014
- Antioxidant properties and inhibitory effects of Satureja khozestanica essential oil on LDL oxidation induced–CuSO4in vitroAsian Pacific Journal of Tropical Biomedicine, 2013
- Berberine, an Isoquinoline Alkaloid in Herbal Plants, Protects Pancreatic Islets and Serum Lipids in Nonobese Diabetic MiceJournal of Agricultural and Food Chemistry, 2011
- Influences of crude extract of tea leaves, Camellia sinensis, on streptozotocin diabetic male albino miceSaudi Journal of Biological Sciences, 2010
- Biological Activities of Phenolic Compounds Present in Virgin Olive OilInternational Journal of Molecular Sciences, 2010
- Epigallocatechin gallate (EGCG) mimics insulin action on the transcription factor FOXO1a and elicits cellular responses in the presence and absence of insulinCellular Signalling, 2006
- Relationship between Serum Lipoprotein Ratios and Insulin Resistance in ObesityClinical Chemistry, 2004
- Mediterranean diet and all-causes mortality after myocardial infarction: results from the GISSI-Prevenzione trialEuropean Journal of Clinical Nutrition, 2003