Body mass index moderates the association between gait kinetics, body composition, and femoral knee cartilage characteristics
- 12 March 2020
- journal article
- research article
- Published by Wiley in Journal of Orthopaedic Research
- Vol. 38 (12), 2685-2695
- https://doi.org/10.1002/jor.24655
Abstract
This study compared femoral cartilage characteristics between age‐ and sex‐matched individuals with (n=48, Age=22.8±3.5 years; BMI=33.1±4.1 kg/m2) and without obesity (n=48 Age=22.0±2.6 years; BMI=21.7±1.7 kg/m2) and evaluated the associations between body composition, quadriceps function, and gait kinetics with femoral cartilage characteristics. Medial and lateral femoral cartilage thickness, medial:lateral thickness ratio, and medial and lateral cartilage echo intensity were measured using ultrasound imaging. Body composition was assessed using air displacement plethysmography. Quadriceps function was assessed via maximal isometric knee extension. Three‐dimensional gait biomechanics were recorded to extract peak external knee flexion and adduction moments, and peak loading rate of the vertical ground reaction force. Cartilage outcomes were compared between groups using one‐way MANOVA. Stepwise moderated regression evaluated the association between body composition, quadriceps function, and gait kinetics with femoral cartilage outcomes in individuals with and without obesity. Medial (75.24 vs. 65.84; p2=0.09–0.12) in individuals with obesity. A higher knee adduction moment was associated with a larger medial:lateral thickness ratio (ΔR2=0.09) in individuals without obesity. No associations were found between quadriceps function and cartilage outcomes. These findings suggest that high body fat in adults with obesity is associated with cartilage echo intensity. Obese BMI was also associated with a lack of a positive relationship between cartilage thickness and joint loading during walking.Keywords
This publication has 43 references indexed in Scilit:
- Dyslipidemia in Obesity: Mechanisms and Potential TargetsNutrients, 2013
- Challenges in dealing with walking speed in knee osteoarthritis gait analysesClinical Biomechanics, 2012
- Articular cartilage and subchondral bone in the pathogenesis of osteoarthritisAnnals of the New York Academy of Sciences, 2010
- Imaging the joint in osteoarthritis: a place for ultrasound?Best Practice & Research Clinical Rheumatology, 2010
- Quadriceps strength and the risk of cartilage loss and symptom progression in knee osteoarthritisArthritis & Rheumatism, 2008
- The relationship between body composition and knee cartilage volume in healthy, middle‐aged subjectsArthritis & Rheumatism, 2005
- The Impact of OsteoarthritisClinical Orthopaedics & Related Research, 2004
- Functional adaptation of human joints to mechanical stimuliOsteoarthritis and Cartilage, 2002
- A gait analysis data collection and reduction techniqueHuman Movement Science, 1991
- Interaction between active and passive knee stabilizers during level walkingJournal of Orthopaedic Research, 1991