MicroRNA-552 expression in colorectal cancer and its clinicopathological significance
Open Access
- 15 March 2021
- journal article
- research article
- Published by The Korean Society of Pathologists and The Korean Society for Cytopathology in Journal of Pathology and Translational Medicine
- Vol. 55 (2), 125-131
- https://doi.org/10.4132/jptm.2021.01.17
Abstract
Background: MicroRNA-552 (MR-552) has been reported to correlate with the development and progression of various cancers, including colorectal cancer (CRC). This study aimed to investigate miR-552 expression in cancer tissue samples compared to normal mucosal tissue and its role as a diagnostic or prognostic marker in CRC patients. Methods: Normal mucosal tissues and primary cancer tissues from 80 surgically resected CRC specimens were used. Quantitative real-time polymerase chain reaction was performed for miR-552 and U6 small nuclear RNA to analyze miR-552 expression and its clinicopathological significance. Immunohistochemistry for p53 and phosphatase and tension homolog (PTEN) was performed to evaluate their association with miR-552 expression. Results: miR-552 expression was significantly higher in primary cancer tissues compared to normal mucosal tissues (p< .001). The expression level of miR552 was inversely correlated with that of PTEN (p= .068) and p53 (p= .004). Survival analysis showed that high miR-552 expression was associated with worse prognosis but this was not statistically significant (p= .255). However, patients with CRC having high rniR-552 expression and loss of PTEN expression had significantly worse prognosis than others (p=.029). Conclusions: Our results suggest that high miR-552 expression might be a potential diagnostic biomarker for CRC, and its combined analysis with PTEN expression can possibly be used as a prognostic marker.Keywords
Funding Information
- Seoul National University (800- 20190384)
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