ALK1 regulates the internalization of endoglin and the type III TGF-β receptor
Open Access
- 1 April 2021
- journal article
- research article
- Published by American Society for Cell Biology (ASCB) in Molecular Biology of the Cell
- Vol. 32 (7), 605-621
- https://doi.org/10.1091/mbc.e20-03-0199
Abstract
The relation between complex formation among TGF-β receptors and their endocytosis remained unclear. We show that the complexes formed regulate their endocytosis and signaling, with a major effect by ALK1. Our results link TGF-β receptor oligomerization and endocytosis based on which endocytosis signals are functional in specific receptor complexes.Keywords
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