Enterococcal Physiology and Antimicrobial Resistance: The Streetlight Just Got a Little Brighter
Open Access
- 23 February 2021
- journal article
- editorial
- Published by American Society for Microbiology in mBio
- Vol. 12 (1)
- https://doi.org/10.1128/mbio.03511-20
Abstract
Enterococcus faecalis differs from many other common human pathogens in its physiology and in its susceptibility to antimicrobial agents. Multiresistant E. faecalis strains owe their phenotypes to a combination of intrinsic and acquired antimicrobial resistance determinants. Acquired resistance is due to E. faecalis frequenting multicultural environments, its capacity to mate with different species, and the nullification of its own defense mechanisms in some lineages. Intrinsic resistance is a complex phenomenon that is intimately tied to the physiology of the species. In their recent study in mBio, Gilmore and colleagues (M. S. Gilmore, R. Salamzade, E. Selleck, N. Bryan, et al., mBio 11:e02962-20, 2020, https://doi.org/10.1128/mBio.02962-20) use functional genomics to explore the genetic underpinnings of E. faecalis physiology and antimicrobial resistance. While they do not come up with many definitive answers, their work points the way toward new and fruitful areas of investigation.Keywords
This publication has 13 references indexed in Scilit:
- Genes Contributing to the Unique Biology and Intrinsic Antibiotic Resistance of Enterococcus faecalismBio, 2020
- Tracing the Enterococci from Paleozoic Origins to the HospitalCell, 2017
- Mechanism of chromosomal transfer of Enterococcus faecalis pathogenicity island, capsule, antimicrobial resistance, and other traitsProceedings of the National Academy of Sciences, 2010
- Characterization of Tn1546, a Tn3-related transposon conferring glycopeptide resistance by synthesis of depsipeptide peptidoglycan precursors in Enterococcus faecium BM4147Journal of Bacteriology, 1993
- Studies on antibiotic synergism against enterococciJCI Insight, 1971
- ALDONIC ACID METABOLISM I. Streptococcus faecalisJournal of Bacteriology, 1957