Diffuse large B-cell lymphoma of the rectum in a patient with Crohn’s disease
- 16 April 2020
- journal article
- research article
- Published by BMJ in BMJ Case Reports
- Vol. 13 (4), e228818
- https://doi.org/10.1136/bcr-2018-228818
Abstract
A 62-year-old man presented to our institute with diarrhoea and dysuria on a background of subtotal colectomy and end ileostomy and biological therapy for Crohn’s disease. He was diagnosed with urinary tract infection and acute kidney injury (AKI). Renal ultrasound suggested left hydronephrosis, with renal protocol computed tomography (CT) showing a large pelvic mass. Magnetic resonance imaging (MRI) of the pelvis demonstrated a rectal tumour invading the bladder and compressing both ureters. He underwent cystoscopy, flexible sigmoidoscopy and positron emission tomography–CT and was diagnosed with stage IV non-Hodgkin’s diffuse large B-cell lymphoma. He was treated primarily with rituximab, cyclophosphamide, hydroxydaunomycin, oncovin and prednisolone chemotherapy regimen. He had ongoing urosepsis before admission for pelvic exenteration. He underwent cystoprostatectomy, excision of rectal stump and formation of ileal conduit. Histology showed no signs of residual malignancy. One year later, the patient was admitted to the intensive care unit with aspiration pneumonia, urosepsis and AKI. Despite maximal therapy, he developed multiorgan failure and passed away.Keywords
This publication has 13 references indexed in Scilit:
- Primary colorectal lymphoma – A single centre experienceThe Surgeon, 2015
- Adverse symptoms with anti-TNF-alpha therapy in inflammatory bowel disease: systematic review and duration-response meta-analysisEuropean Journal of Clinical Pharmacology, 2015
- Lymphoproliferative disorders in inflammatory bowel disease patients on immunosuppression: Lessons from other inflammatory disordersWorld Journal of Gastrointestinal Pathophysiology, 2015
- Medical History, Lifestyle, Family History, and Occupational Risk Factors for Diffuse Large B-Cell Lymphoma: The InterLymph Non-Hodgkin Lymphoma Subtypes ProjectJNCI Monographs, 2014
- Optimization of the treatment with immunosuppressants and biologics in inflammatory bowel diseaseWorld Journal of Gastroenterology, 2014
- Primary intestinal lymphoma in patients with inflammatory bowel diseaseInflammatory Bowel Diseases, 2011
- A decade of infliximab: The Austrian evidence based consensus on the safe use of infliximab in inflammatory bowel diseaseJournal of Crohn's and Colitis, 2010
- Lymphoproliferative disorders in patients receiving thiopurines for inflammatory bowel disease: a prospective observational cohort studyThe Lancet, 2009
- The risk of lymphoma in the treatment of inflammatory bowel disease with immunosuppressive agentsCritical Reviews in Oncology/Hematology, 2005
- Epstein-Barr virus–positive lymphoma in patients with inflammatory bowel disease treated with azathioprine or 6-mercaptopurineGastroenterology, 2002