A Systematic Review on Cornea Epithelial-Stromal Homeostasis
- 29 May 2020
- journal article
- review article
- Published by S. Karger AG in Ophthalmic Research
- Vol. 64 (2), 178-191
- https://doi.org/10.1159/000509030
Abstract
Introduction This review aims to summarise the role of different cells, genes, proteins and lipid in regulating cornea epithelial-stromal homeostasis. Methods We performed an Entrez PubMed literature search using keywords ‘human’, ‘cornea’, ‘epithelial’, ‘stromal’, ‘homeostasis’, ‘fibrosis response’, and ‘pathogenesis’ on 24th of September 2019, resulting in 35 papers, of which 18 were chosen after filtering for ‘English language’ and ‘published within 10 years’ as well as curation for relevance by the authors. Results The 18 selected papers showed that corneal epithelial cells, fibroblasts and telocytes, together with genes such as Klf4, Pax6 and Id found in the cells, play important roles in achieving homeostasis to maintain corneal integrity and transparency. Proteins classified as pro-fibrotic ligands and anti-fibrotic ligands are responsible for regulating cornea stromal fibrosis and extracellular matrix deposition, thus regulators of scar formation during wound healing. Anti-inflammatory ligands and wound repairing ligands are critical in eliciting protective inflammation and promoting epithelial healing respectively. Protein receptors located on cellular membrane play a role in maintaining intercellular connections as well as corneal hydration. Discussion/ Conclusion These studies prompt development of novel therapeutic strategies such as tear drops or ointments that target certain proteins to maintain corneal homeostasis. However, more in vitro and in vivo studies are required to prove the effectiveness of exogenous administration of molecules in improving healing outcome. Hence, more future investigation of the molecular pathways highlighted in this review will reveal novel therapeutic tools such as gene or cell therapy to treat corneal diseases.Keywords
This publication has 72 references indexed in Scilit:
- Protein Phosphatase Magnesium Dependent 1A (PPM1A) Plays a Role in the Differentiation and Survival Processes of Nerve CellsPLOS ONE, 2012
- Effects of Aberrant Pax6 Gene Dosage on Mouse Corneal Pathophysiology and Corneal Epithelial HomeostasisPLOS ONE, 2011
- Proteome profiling of wild type and lumican-deficient mouse corneasJournal of Proteomics, 2011
- VIP and Growth Factors in the Infected CorneaInvestigative Opthalmology & Visual Science, 2011
- Mitochondrial Dysfunction Links Ceramide Activated HRK Expression and Cell DeathPLOS ONE, 2011
- Gene therapy for ocular diseasesBritish Journal of Ophthalmology, 2010
- Transforming Growth Factor-α Enhances Corneal Epithelial Cell Migration by Promoting EGFR RecyclingInvestigative Opthalmology & Visual Science, 2010
- Induction of corneal myofibroblasts by lens-derived transforming growth factor β1 (TGFβ1): A transgenic mouse modelBrain Research Bulletin, 2010
- Functions of aquaporins in the eyeProgress in Retinal and Eye Research, 2008
- Conditional Deletion of the Mouse Klf4 Gene Results in Corneal Epithelial Fragility, Stromal Edema, and Loss of Conjunctival Goblet CellsMolecular and Cellular Biology, 2007