Ultrasonic Interfacial Engineering of Red Phosphorous–Metal for Eradicating MRSA Infection Effectively
Top Cited Papers
- 22 December 2020
- journal article
- research article
- Published by Wiley in Advanced Materials
- Vol. 33 (5), e2006047
- https://doi.org/10.1002/adma.202006047
Abstract
Sonodynamic therapy (SDT) is considered to be a potential treatment for various diseases including cancers and bacterial infections due to its deep penetration ability and biosafety, but its SDT efficiency is limited by the hypoxia environment of deep tissues. This study proposes creating a potential solution, sonothermal therapy, by developing the ultrasonic interfacial engineering of metal–red phosphorus (RP), which has an obviously improved sonothermal ability of more than 20 °C elevation under 25 min of continuous ultrasound (US) excitation as compared to metal alone. The underlying mechanism is that the mechanical energy of the US activates the motion of the interfacial electrons. US‐induced electron motion in the RP can efficiently transfer the US energy into phonons in the forms of heat and lattice vibrations, resulting in a stronger US absorption of metal–RP. Unlike the nonspecific heating of the cavitation effect induced by US, titanium–RP can be heated in situ when the US penetrates through 2.5 cm of pork tissue. In addition, through a sonothermal treatment in vivo, bone infection induced by multidrug‐resistant Staphylococcus aureus (MRSA) is successfully eliminated in under 20 min of US without tissue damage. This work provides a new strategy for combating MRSA by strong sonothermal therapy through US interfacial engineering.Keywords
Funding Information
- National Natural Science Foundation of China (51801056, 51671081, 51871162)
This publication has 53 references indexed in Scilit:
- Cancer overdiagnosis: a biological challenge and clinical dilemmaNature Reviews Cancer, 2019
- Local Cancer Recurrence: The Realities, Challenges, and Opportunities for New TherapiesCA: A Cancer Journal for Clinicians, 2018
- Synergistic Sonodynamic/Chemotherapeutic Suppression of Hepatocellular Carcinoma by Targeted Biodegradable Mesoporous NanosonosensitizersAdvanced Functional Materials, 2018
- Insights into the unique functionality of inorganic micro/nanoparticles for versatile ultrasound theranosticsBiomaterials, 2017
- Diagnostic accuracy of multi-parametric MRI and TRUS biopsy in prostate cancer (PROMIS): a paired validating confirmatory studyThe Lancet, 2017
- Safety and efficacy of minimally invasive surgery plus alteplase in intracerebral haemorrhage evacuation (MISTIE): a randomised, controlled, open-label, phase 2 trialThe Lancet Neurology, 2016
- Overcoming the Achilles' heel of photodynamic therapyChemical Society Reviews, 2016
- Antibacterial drug discovery in the resistance eraNature, 2016
- Light-Emitting Diodes (LEDs) in DermatologySeminars in Cutaneous Medicine and Surgery, 2008
- High-intensity focused ultrasound in the treatment of solid tumoursNature Reviews Cancer, 2005