Multi-Level Regulation of Opioid-Induced Respiratory Depression
- 1 November 2020
- journal article
- review article
- Published by American Physiological Society in Physiology
- Vol. 35 (6), 391-404
- https://doi.org/10.1152/physiol.00015.2020
Abstract
Opioids depress minute ventilation primarily by reducing respiratory rate. This results from direct effects on the preBotzinger Complex as well as from depression of the Parabrachial/Kalliker-Fuse Complex, which provides excitatory drive to preBotzinger Complex neurons mediating respiratory phase-switch. Opioids also depress awake drive from the forebrain and chemodrive.Keywords
Funding Information
- HHS | NIH | National Institute of General Medical Sciences (R01-GM112960)
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