The Role of Autophagy in White Adipose Tissue Function: Implications for Metabolic Health
Open Access
- 30 April 2020
- journal article
- review article
- Published by MDPI AG in Metabolites
- Vol. 10 (5), 179
- https://doi.org/10.3390/metabo10050179
Abstract
White adipose tissue (WAT) is a highly adaptive endocrine organ that continuously remodels in response to nutritional cues. WAT expands to store excess energy by increasing adipocyte number and/or size. Failure in WAT expansion has serious consequences on metabolic health resulting in altered lipid, glucose, and inflammatory profiles. Besides an impaired adipogenesis, fibrosis and low-grade inflammation also characterize dysfunctional WAT. Nevertheless, the precise mechanisms leading to impaired WAT expansibility are yet unresolved. Autophagy is a conserved and essential process for cellular homeostasis, which constitutively allows the recycling of damaged or long-lived proteins and organelles, but is also highly induced under stress conditions to provide nutrients and remove pathogens. By modulating protein and organelle content, autophagy is also essential for cell remodeling, maintenance, and survival. In this line, autophagy has been involved in many processes affected during WAT maladaptation, including adipogenesis, adipocyte, and macrophage function, inflammatory response, and fibrosis. WAT autophagy dysregulation is related to obesity and diabetes. However, it remains unclear whether WAT autophagy alteration in obese and diabetic patients are the cause or the consequence of WAT malfunction. In this review, current data regarding these issues are discussed, focusing on evidence from human studies.Keywords
Funding Information
- Ministerio de Ciencia, Innovación y Universidades (Juan de la Cierva Formación (FJCI-2017-32194), CB06/03/0018, RIC-0539-2018 and PI-0092-2017, PI18/01160)
- Fondo Europeo de Desarrollo Regional ((FEDER))
This publication has 185 references indexed in Scilit:
- Macrophages and fibrosis: How resident and infiltrating mononuclear phagocytes orchestrate all phases of tissue injury and repairBiochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2013
- In Vivo Identification of Bipotential Adipocyte Progenitors Recruited by β3-Adrenoceptor Activation and High-Fat FeedingCell Metabolism, 2012
- Autophagy in Hypothalamic AgRP Neurons Regulates Food Intake and Energy BalanceCell Metabolism, 2011
- Microautophagy of Cytosolic Proteins by Late EndosomesDevelopmental Cell, 2011
- The Beclin 1 interactomeCurrent Opinion in Cell Biology, 2010
- Adipose-specific deletion of autophagy-related gene 7 ( atg7 ) in mice reveals a role in adipogenesisProceedings of the National Academy of Sciences, 2009
- Inflammation and metabolic disordersNature, 2006
- Sequential phosphorylation of CCAAT enhancer-binding protein β by MAPK and glycogen synthase kinase 3β is required for adipogenesisProceedings of the National Academy of Sciences, 2005
- Role of CREB in Transcriptional Regulation of CCAAT/Enhancer-binding Protein β Gene during AdipogenesisJournal of Biological Chemistry, 2004
- CCAAT/enhancer-binding protein β is required for mitotic clonal expansion during adipogenesisProceedings of the National Academy of Sciences, 2003