Non-invasive drug delivery technology: development and current status of transdermal drug delivery devices, techniques and biomedical applications
- 20 November 2019
- journal article
- review article
- Published by Walter de Gruyter GmbH in Biomedizinische Technik/Biomedical Engineering
- Vol. 65 (3), 243-272
- https://doi.org/10.1515/bmt-2019-0019
Abstract
Pay-load deliveries across the skin barrier to the systemic circulation have been one of the most challenging delivery options. Necessitated requirements of the skin and facilitated skin layer cross-over delivery attempts have resulted in development of different non-invasive, non-oral methods, devices and systems which have been standardized, concurrently used and are in continuous upgrade and improvements. Iontophoresis, electroporation, sonophoresis, magnetophoresis, dermal patches, nanocarriers, needled and needle-less shots, and injectors are among some of the methods of transdermal delivery. The current review covers the current state of the art, merits and shortcomings of the systems, devices and transdermal delivery patches, including drugs’ and other payloads’ passage facilitation techniques, permeation and absorption feasibility studies, as well as physicochemical properties affecting the delivery through different transdermal modes along with examples of drugs, vaccines, genes and other payloads.Keywords
This publication has 252 references indexed in Scilit:
- Sodium Alginate Microneedle Arrays Mediate the Transdermal Delivery of Bovine Serum AlbuminPLOS ONE, 2013
- Titanium dioxide nanoparticles: a review of current toxicological dataParticle and Fibre Toxicology, 2013
- Hydrogel‐Forming Microneedle Arrays for Enhanced Transdermal Drug DeliveryAdvanced Functional Materials, 2012
- Stability of influenza vaccine coated onto microneedlesBiomaterials, 2012
- Skin permeating nanogel for the cutaneous co-delivery of two anti-inflammatory drugsBiomaterials, 2012
- The Rule of Five for Non-Oral Routes of Drug Delivery: Ophthalmic, Inhalation and TransdermalPharmaceutical Research, 2010
- Transdermal Delivery of Naltrexol and Skin Permeability Lifetime after Microneedle Treatment in Hairless Guinea PigsJournal of Pharmaceutical Sciences, 2010
- Rapid Intradermal Delivery of Liquid Formulations Using a Hollow Microstructured ArrayPharmaceutical Research, 2010
- Design, Optimization and Characterisation of Polymeric Microneedle Arrays Prepared by a Novel Laser-Based Micromoulding TechniquePharmaceutical Research, 2010
- In Vivo Methods for the Assessment of Topical Drug BioavailabilityPharmaceutical Research, 2007