Dual Cherenkov Radiation-Induced Near-Infrared Luminescence Imaging and Photodynamic Therapy toward Tumor Resection
- 24 July 2020
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 63 (17), 9446-9456
- https://doi.org/10.1021/acs.jmedchem.0c00625
Abstract
Cherenkov Radiation (CR), the blue light seen in nuclear reactors is emitted by some radiopharmaceuticals. This study showed that 1) a portion of CR could be transferred in the region of the optical spectrum where biological tissues are most transparent: as a result, upon radiance amplification in the NIR window, the detection of light could occur twice deeper in tissues than during classical Cherenkov Luminescence Imaging (CLI). 2) Cherenkov-Photodynamic Therapy (CR-PDT) on cells could be achieved under conditions mimicking unlimited depth using CR embarked light source, which is unlike standard Photodynamic Therapy (PDT) where light penetration depth is limited in biological tissues. Both results are of utmost importance for simultaneous applications in tumor resection and post-resection treatment of remaining un-resected margins, thanks to a molecular construct designed to raise its light collection efficiency (i.e. CR Energy Transfer (CRET)) by conjugation with multiple CR-absorbing (water-soluble) antenna followed by intramolecular-FRET/TBET energy transfers.Funding Information
- Agence Nationale de la Recherche (ANR-10-EQPX-05-01/IMAPPI)
- European Regional Development Fund
- Centre National de la Recherche Scientifique
- Fondation de Coop?ration Scientifique Bourgogne Franche-Comte
- Canc?rop?le Est
This publication has 65 references indexed in Scilit:
- Enhancement of Cerenkov Luminescence Imaging by Dual Excitation of Er3+, Yb3+-Doped Rare-Earth MicroparticlesPLOS ONE, 2013
- Quantitative Modeling of Cerenkov Light Production Efficiency from Medical RadionuclidesPLOS ONE, 2012
- Like a Bolt from the Blue: Phthalocyanines in Biomedical OpticsMolecules, 2011
- In vivo Cerenkov luminescence imaging: a new tool for molecular imagingPhilosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 2011
- Harnessing the Power of Radionuclides for Optical Imaging: Cerenkov Luminescence ImagingJournal of Nuclear Medicine, 2011
- Cerenkov Radiation Energy Transfer (CRET) Imaging: A Novel Method for Optical Imaging of PET Isotopes in Biological SystemsPLOS ONE, 2010
- Cerenkov Luminescence Imaging of Medical IsotopesJournal of Nuclear Medicine, 2010
- Molecular Optical Imaging with Radioactive ProbesPLOS ONE, 2010
- Second window for in vivo imagingNature Nanotechnology, 2009
- Optical imaging of Cerenkov light generation from positron-emitting radiotracersPhysics in Medicine & Biology, 2009