Prevalence of canine primary hyperparathyroidism recurrence in Keeshond and non‐Keeshond dogs after curative parathyroidectomy
- 20 July 2020
- journal article
- research article
- Published by Wiley in Veterinary Record
- Vol. 187 (11), e93
- https://doi.org/10.1136/vr.105563
Abstract
Background Primary hyperparathyroidism (PHPT) is an uncommon condition in dogs, for which there is a documented genetic predisposition in Keeshonden and sporadic cases in other breeds. Secondary literature reports a 10 per cent prevalence for recurrence in patients successfully treated by surgical parathyroidectomy, however there is no published primary literature available on which to base this assertion. This study sought to document prevalence of recurrence within Keeshonden and non-Keeshonden breeds. The authors hypothesised that Keeshonden would have a higher rate of recurrence due to the genetic predisposition for the disease, as compared with sporadic cases in other breeds, and that Keeshonden might have an earlier age of detection of disease. Methods A retrospective review of medical records was undertaken to assess the prevalence of recurrence, the length of time after diagnosis that the recurrence occurred, and the age of initial diagnosis in both Keeshonden and non-Keeshonden breeds. Results The study found that Keeshonden were significantly more likely to develop recurrence (6/12, 50 per cent) than non-Keeshonden dogs (1/15, 7 per cent) (P=0.024), and were significantly younger (median 108 v 126 months, P=0.043) at initial disease detection. Recurrence in Keeshonden occurred at median 35 months after treatment. Conclusion This suggests all dogs treated by curative parathyroidectomy for PHPT should be monitored lifelong for recurrence of disease, and that this is particularly pertinent in the Keeshond population. Earlier screening of younger, apparently healthy Keeshonden may also be advisable.Keywords
This publication has 18 references indexed in Scilit:
- Mutations Affecting G-Protein Subunit α11in Hypercalcemia and HypocalcemiaNew England Journal of Medicine, 2013
- Mutations in AP2S1 cause familial hypocalciuric hypercalcemia type 3Nature Genetics, 2012
- Whole-Exome Sequencing Studies of Nonhereditary (Sporadic) Parathyroid AdenomasJournal of Clinical Endocrinology & Metabolism, 2012
- No recurrence of sporadic primary hyperparathyroidism when cure is established 6 months after parathyroidectomyActa Endocrinologica, 2010
- Validation of a Rapid Parathyroid Hormone Assay and Intraoperative Measurement of Parathyroid Hormone in Dogs with Benign Naturally Occurring Primary HyperparathyroidismVeterinary Surgery, 2008
- Unilateral Versus Bilateral Neck Exploration for Primary HyperparathyroidismAnnals of Surgery, 2007
- Mutations in genes causing human familial isolated hyperparathyroidism do not account for hyperparathyroidism in Keeshond dogsThe Veterinary Journal, 2007
- A 10-Year Prospective Study of Primary Hyperparathyroidism with or without Parathyroid SurgeryNew England Journal of Medicine, 1999
- Renal OsteodystrophyNew England Journal of Medicine, 1995
- Hypercalcemia of malignancy revisited.JCI Insight, 1988