Molecular characteristics of the re‐emerged avian leukosis virus in China, 2018–2019
- 3 January 2020
- journal article
- research article
- Published by Hindawi Limited in Transboundary and Emerging Diseases
- Vol. 67 (3), 1141-1151
- https://doi.org/10.1111/tbed.13440
Abstract
Since early 2018, avian leukosis virus (ALV) has re-emerged throughout six provinces in Northeast and East of China and caused huge economic losses. In different farms, there are significant differences in clinical symptoms, including morbidity, mortality and location of tumours, on affected animals, which implies that the present strains may have different origins and molecular characteristics. In this study, a systematic epidemiological investigation was conducted in 21 farms in six provinces. Results showed that the virus strains present in this outbreak are highly consistent but carry different mutations. All the strains shared 97.0%-99.0% identity with each other and were highly similar to the GD14J2 strain isolated previously, while different insertion fragments can be found in the env gene of different strains, suggesting that the strains of ALV in this outbreak may have the same ancestors but have gone through different evolutionary trajectories. This study demonstrated that these viruses may point to multiple sources of infection, and all should be identified and taken seriously in the formulation of control plans.Keywords
This publication has 32 references indexed in Scilit:
- A 205-Nucleotide Deletion in the 3′ Untranslated Region of Avian Leukosis Virus Subgroup J, Currently Emergent in China, Contributes to Its PathogenicityJournal of Virology, 2012
- Genetic diversity and phylogenetic analysis of glycoprotein GP85 of ALV-J isolates from Mainland China between 1999 and 2010: Coexistence of two extremely different subgroups in layersVeterinary Microbiology, 2012
- 100 years of Rous sarcoma virusThe Journal of Experimental Medicine, 2011
- Avian Leukosis Virus Subgroup J in Layer Chickens, ChinaEmerging Infectious Diseases, 2010
- Reduced Serologic Response to Newcastle Disease Virus in Broiler Chickens Exposed to a Chinese Field Strain of Subgroup J Avian Leukosis VirusAvian Diseases, 2006
- Comparison of Chinese Field Strains of Avian Leukosis Subgroup J Viruses with Prototype Strain HPRS-103 and United States StrainsAvian Diseases, 2003
- Identification and Characterization of Recombinant Subgroup J Avian Leukosis Viruses (ALV) Expressing Subgroup A ALV EnvelopeVirology, 2000
- Tissue Tropism of the HPRS-103 Strain of J Subgroup Avian Leukosis Virus and of a Derivative Acutely Transforming VirusVeterinary Pathology, 1997
- A novel subgroup of exogenous avian leukosis virus in chickensJournal of General Virology, 1991
- Occurrence of different subgroups of avian leukosis virus in finnish poultryAvian Pathology, 1974