Computational Fluid Simulation of Fibrinogen around Dental Implant Surfaces
Open Access
- 19 January 2020
- journal article
- research article
- Published by MDPI AG in International Journal of Molecular Sciences
- Vol. 21 (2), 660
- https://doi.org/10.3390/ijms21020660
Abstract
Ultraviolet treatment of titanium implants makes their surfaces hydrophilic and enhances osseointegration. However, the mechanism is not fully understood. This study hypothesizes that the recruitment of fibrinogen, a critical molecule for blood clot formation and wound healing, is influenced by the degrees of hydrophilicity/hydrophobicity of the implant surfaces. Computational fluid dynamics (CFD) implant models were created for fluid flow simulation. The hydrophilicity level was expressed by the contact angle between the implant surface and blood plasma, ranging from 5° (superhydrophilic), 30° (hydrophilic) to 50° and 70° (hydrophobic), and 100° (hydrorepellent). The mass of fibrinogen flowing into the implant interfacial zone (fibrinogen infiltration) increased in a time dependent manner, with a steeper slope for surfaces with greater hydrophilicity. The mass of blood plasma absorbed into the interfacial zone (blood plasma infiltration) was also promoted by the hydrophilic surfaces but it was rapid and non-time-dependent. There was no linear correlation between the fibrinogen infiltration rate and the blood plasma infiltration rate. These results suggest that hydrophilic implant surfaces promote both fibrinogen and blood plasma infiltration to their interface. However, the infiltration of the two components were not proportional, implying a selectively enhanced recruitment of fibrinogen by hydrophilic implant surfaces.Keywords
This publication has 37 references indexed in Scilit:
- The Effects of Different Wavelength UV Photofunctionalization on Micro-Arc Oxidized TitaniumPLOS ONE, 2013
- Nonvolatile buffer coating of titanium to prevent its biological aging and for drug deliveryBiomaterials, 2010
- Electrostatic control of protein adsorption on UV-photofunctionalized titaniumActa Biomaterialia, 2010
- Ultraviolet Treatment Overcomes Time-Related Degrading Bioactivity of TitaniumTissue Engineering, Part A, 2009
- The effect of UV-photofunctionalization on the time-related bioactivity of titanium and chromium–cobalt alloysBiomaterials, 2009
- Diffusion of Insulin-Like Growth Factor-I and Ribonuclease through Fibrin GelsBiophysical Journal, 2007
- AFM force spectroscopy of the fibrinogen adsorption process onto dental implantsJournal of Biomedical Materials Research Part A, 2006
- Interfacial Tension of Some Biological Fluids: A Comparative Studycclm, 1981
- Determination of serum and blood densitiesAnalytical Chemistry, 1979
- The viscosity of human blood plasma: its change in disease and on the exhibition of drugsRheologica Acta, 1971