Supplementary Figures S1-S7. Figure S1 contains the cell survival data of H3122 cells to multiple ALK-TKIs. Figure S2 contains the comparison of experimental IC50 values and calculated free energy values corresponding to Fig 3C. Figure S3 contains the IC50 values of Ba/F3 cells following treatment with various ALK-TKIs corresponding to Fig3A and 4A. Figure S4 contains the cell survival data of Ba/F3 cells to ASP3026 and AP26113. Figure S5 contains the immunoblot data of Ba/F3 cells treated with various ALK-TKIs. Figure S6 contains the apoptosis assay of alectinib resistant H3122 CHR-A1 cells following treatment with various ALK-TKIs. Figure S7 contains the cell survival data and immunoblot data of Hsp90 inhibitor treated cells.