Syphilis: using modern approaches to understand an old disease
Top Cited Papers
- 1 December 2011
- journal article
- review article
- Published by American Society for Clinical Investigation in JCI Insight
- Vol. 121 (12), 4584-4592
- https://doi.org/10.1172/jci57173
Abstract
Syphilis is a fascinating and perplexing infection, with protean clinical manifestations and both diagnostic and management ambiguities. Treponema pallidum subsp. pallidum, the agent of syphilis, is challenging to study in part because it cannot be cultured or genetically manipulated. Here, we review recent progress in the application of modern molecular techniques to understanding the biological basis of this multistage disease and to the development of new tools for diagnosis, for predicting efficacy of treatment with alternative antibiotics, and for studying the transmission of infection through population networks.Keywords
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