Induction of peroxisomal β-oxidation genes by retinoic acid in cultured rat hepatocytes
- 1 January 1992
- journal article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 281 (1), 41-43
- https://doi.org/10.1042/bj2810041
Abstract
Retinoic acid is reported here to induce peroxisomal beta-oxidation activities in cultured rat hepatocytes, with a concomitant increase in respective peroxisomal mRNAs. The concentrations of retinoic acid required for inducing liver peroxisomal acyl-CoA oxidase were similar to those required for inducing liver transglutaminase. A putative 5′-flanking response element for retinoic acid may be found within the enhancer region involved in the induction of peroxisomal genes by xenobiotic amphipathic carboxylates.Keywords
This publication has 20 references indexed in Scilit:
- Two
cis -acting regulatory sequences in the peroxisome proliferator-responsive enhancer region of rat acyl-CoA oxidase geneBiochemical and Biophysical Research Communications, 1991 - Identification and characterization of nuclear retinoic acid-binding activity in human myeloblastic leukemia HL-60 cells.Proceedings of the National Academy of Sciences, 1989
- The induction of liver peroxisomal proliferation by β,β′-methyl-substituted hexadecanedioic acid (MEDICA 16)Biochemical Pharmacology, 1988
- Microsomal cytochrome P-452 induction and peroxisome proliferation by hypolipidaemic agents in rat liverBiochemical Pharmacology, 1988
- The effect of bezafibrate and long-chain fatty acids on peroxisomal activities in cultured rat hepatocytesBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1985
- Evaluation of Selected Hypolipidemic Agents for the Induction of Peroxisomal Enzymes and Peroxisome Proliferation in the Rat LiverHuman Toxicology, 1983
- Isolation of biologically active ribonucleic acid from sources enriched in ribonucleaseBiochemistry, 1979
- Hepatic peroxisome (microbody) proliferation in rats fed plasticizers and related compoundsToxicology and Applied Pharmacology, 1978
- Primary culture of parenchymal liver cells on collagen membranesExperimental Cell Research, 1975
- HIGH-YIELD PREPARATION OF ISOLATED RAT LIVER PARENCHYMAL CELLSThe Journal of cell biology, 1969