Neurocognitive dysfunction and psychosocial outcome in patients with bipolar I disorder at 15‐year follow‐up
- 5 November 2010
- journal article
- Published by Wiley in Acta Psychiatrica Scandinavica
- Vol. 122 (6), 499-506
- https://doi.org/10.1111/j.1600-0447.2010.01590.x
Abstract
Burdick KE, Goldberg JF, Harrow M. Neurocognitive dysfunction and psychosocial outcome in patients with bipolar I disorder at 15‐year follow‐up. Objective: Despite increasing interest in cognitive dysfunction in bipolar disorder, little is known about its impact on functional outcome relative to affective symptoms. Method: A total of 33 bipolar I subjects were evaluated at index hospitalization and prospectively followed up 15 years later. Affective symptoms, cognition, global functioning, work, and social adjustment were assessed at follow‐up and analyzed by linear regression. Results: Global functional impairment was significantly associated with poor performance on a cognitive measure of processing speed (WAIS Digit Symbol). Digit symbol performance also was the sole significant predictor of social functioning. Neither symptom severity nor course of illness features significantly contributed to global and social functioning. In contrast, verbal learning deficits, recent depression, and lifetime hospitalizations all were independently associated with work disability. Conclusion: Processing speed is robustly associated with social and global functioning in bipolar disorder. Poor work functioning is significantly related to subsyndromal depression, course of illness, and verbal learning deficits. Cognitive and mood symptoms warrant consideration as independent determinants of functioning in patients with bipolar disorder many years after an index manic episode.Keywords
This publication has 34 references indexed in Scilit:
- Neurocognitive and symptomatic predictors of functional outcome in bipolar disorders: A prospective 1 year follow-up studyJournal of Affective Disorders, 2008
- Neuropsychological profile in bipolar disorder: a preliminary study of monotherapy lithium‐treated euthymic bipolar patients evaluated at a 2‐year intervalActa Psychiatrica Scandinavica, 2008
- Mood Symptoms, Functional Impairment, and Disability in People With Bipolar DisorderThe Journal of Clinical Psychiatry, 2007
- Does cognition predict community function only in schizophrenia?: A study of schizophrenia patients, bipolar affective disorder patients, and community control subjectsSchizophrenia Research, 2006
- Open-label olanzapine treatment in bipolar I disorder: clinical and work functional outcomesCurrent Medical Research and Opinion, 2006
- Consistency of remission and outcome in bipolar and unipolar mood disorders: a 10-year prospective follow-up*1Journal of Affective Disorders, 2004
- Cognitive impairment in euthymic bipolar patients: implications for clinical and functional outcomeBipolar Disorders, 2004
- Association Between Cognitive Functioning and Employment Status of Persons With Bipolar DisorderPsychiatric Services, 2004
- Bipolar I affective disorder: predictors of outcome after 15 yearsJournal of Affective Disorders, 1998
- Recurrent Affective Syndromes in Bipolar and Unipolar Mood Disorders at Follow-UpThe British Journal of Psychiatry, 1995