The distribution of fitness effects of new mutations
Top Cited Papers
- 1 August 2007
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature Reviews Genetics
- Vol. 8 (8), 610-618
- https://doi.org/10.1038/nrg2146
Abstract
The distribution of fitness effects (DFE) is a fundamental entity in genetics that describes what proportion of new mutations are advantageous, neutral or deleterious. The shape of the DFE varies between species and depends on factors such as population size and genome size. The DFE differs between coding and non-coding DNA. Advantageous mutations are rare. The DFE of strongly advantageous mutations has an exponential distribution. The DFE of deleterious mutations is a complex, multi-modal distribution.Keywords
This publication has 91 references indexed in Scilit:
- Understanding the Evolutionary Fate of Finite Populations: The Dynamics of Mutational EffectsPLoS Biology, 2007
- Higher Intensity of Purifying Selection on >90% of the Human Genes Revealed by the Intrinsic Replacement Mutation RatesMolecular Biology and Evolution, 2006
- Ubiquitous selective constraints in the Drosophila genome revealed by a genome-wide interspecies comparisonGenome Research, 2006
- Inferring the distribution of mutational effects on fitness inDrosophilaBiology Letters, 2006
- Distribution of fitness effects among beneficial mutations before selection in experimental populations of bacteriaNature Genetics, 2006
- Genomic Selective Constraints in Murid Noncoding DNAPLoS Genetics, 2006
- Selective Constraint on Noncoding Regions of Hominid GenomesPLoS Computational Biology, 2005
- Evidence for Widespread Degradation of Gene Control Regions in Hominid GenomesPLoS Biology, 2005
- High mutation rate and predominance of insertions in the Caenorhabditis elegans nuclear genomeNature, 2004
- Initial sequencing and comparative analysis of the mouse genomeNature, 2002