The in Vitro Drug Interaction Potential of Dietary Supplements Containing Multiple Herbal Components
Open Access
- 8 November 2006
- journal article
- Published by American Society for Pharmacology & Experimental Therapeutics (ASPET) in Drug Metabolism and Disposition
- Vol. 35 (2), 185-188
- https://doi.org/10.1124/dmd.106.012724
Abstract
Herbal-based remedies are widely used as alternative treatments for a number of ailments. In addition, the use of products that contain both single and multiple herbal constituents is becoming increasingly common. The work described in this report examined the in vitro drug interaction potential for a commonly used herbal cold remedy reported to contain a mixture of eight herbal components. Experiments conducted in human liver microsomes exhibited significant inhibition (<10% of control activity remaining) of multiple cytochrome P450 (P450) isoforms, including CYP2B6, CYP2C9, and CYP2D6, by the herbal mixture. In an attempt to explain the observed P450 inhibition by the herbal mixture, individual active components were obtained and tested for inhibitory potency. Inhibition of multiple P450 activities by a single constituent, luteolin, was observed. Conversely, inhibition of a single isoform by several herbal components was noted for CYP2B6. Based on the data presented, it is concluded that mixtures of herbal components may exhibit multiple modes of P450 inhibition, indicating the potential for complex herbal-drug interaction scenarios to occur.Keywords
This publication has 13 references indexed in Scilit:
- Effects of hydroxyl group numbers on the B-ring of 5,7-dihydroxyflavones on the differential inhibition of human CYP 1A and CYP1B1 enzymesArchives of Pharmacal Research, 2005
- Constituents of Zingiber aromaticum and Their CYP3A4 and CYP2D6 Inhibitory ActivityCHEMICAL & PHARMACEUTICAL BULLETIN, 2005
- INDUCTION AND INHIBITION OF CYTOCHROMES P450 BY THE ST. JOHN'S WORT CONSTITUENT HYPERFORIN IN HUMAN HEPATOCYTE CULTURESPublished by American Society for Pharmacology & Experimental Therapeutics (ASPET) ,2004
- Herbal Interactions Involving Cytochrome P450 EnzymesToxicological Reviews, 2004
- The in-vivo effects of sho-saiko-to, a traditional Chinese herbal medicine, on two cytochrome P450 enzymes (1A2 and 3A) and xanthine oxidase in manJournal of Pharmacy and Pharmacology, 2003
- Drug-Drug Interactions and the Cytochromes P450Published by Informa UK Limited ,2003
- Pharmacokinetic interactions between herbal remedies and medicinal drugsXenobiotica, 2002
- Herb–drug interactions: Review and assessment of report reliabilityBritish Journal of Clinical Pharmacology, 2001
- Incidence of Adverse Drug Reactions in Hospitalized PatientsJAMA, 1998
- The effects of Danshen (Salvia miltiorrhiza) on pharmacokinetics and pharmacodynamics of warfarin in ratsEuropean Journal of Drug Metabolism and Pharmacokinetics, 1992