Macrophages specifically regulate the concentration of their own growth factor in the circulation.
- 1 September 1987
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 84 (17), 6179-6183
- https://doi.org/10.1073/pnas.84.17.6179
Abstract
The physiological mechanism of clearance of the mononuclear phagocyte growth factor, colony-stimulating factor 1 (CSF-1), from the circulation of normal mice was investigated by following the fate of a trace amount of i.v. injected 125I-labeled CSF-1. Macrophages selectively cleared CSF-1 by CSF-1 receptor-mediated endocytosis and degraded the growth factor intracellularly. This manner of clearance provides a feedback control mechanism whereby the rate of macrophage production is determined by the number of mature macrophages.This publication has 28 references indexed in Scilit:
- Uptake and destruction of 125I‐CSF‐1 by peritoneal exudate macrophagesJournal of Cellular Biochemistry, 1986
- Solubilization and assay of a colony-stimulating factor receptor from murine macrophagesJournal of Cellular Biochemistry, 1986
- The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor, CSF 1Cell, 1985
- Sinusoidal Endothelial Cells from Normal Guinea Pig Liver: Isolation, Culture and CharacterizationHepatology, 1984
- Survival of mononuclear phagocytes depends on a lineage-specific growth factor that the differentiated cells selectively destroyCell, 1982
- Distribution of cells bearing receptors for a colony-stimulating factor (CSF-1) in murine tissues.The Journal of cell biology, 1981
- Specific interaction of murine colony-stimulating factor with mononuclear phagocytic cells.The Journal of cell biology, 1980
- Clonal growth in vitro by mouse Kupffer cellsExperimental Cell Research, 1979
- Cyclic expression of a growth conditioning factor (MGF) on the cell surfaceNature, 1974
- A low molecular weight factor in lung‐conditioned medium stimulating granulocyte and monocyte colony formation in vitroJournal of Cellular Physiology, 1973