Stem cells in clinical practice: applications and warnings
Open Access
- 17 January 2011
- journal article
- review article
- Published by Springer Science and Business Media LLC in Journal of Experimental & Clinical Cancer Research
- Vol. 30 (1), 9-20
- https://doi.org/10.1186/1756-9966-30-9
Abstract
Stem cells are a relevant source of information about cellular differentiation, molecular processes and tissue homeostasis, but also one of the most putative biological tools to treat degenerative diseases. This review focuses on human stem cells clinical and experimental applications. Our aim is to take a correct view of the available stem cell subtypes and their rational use in the medical area, with a specific focus on their therapeutic benefits and side effects. We have reviewed the main clinical trials dividing them basing on their clinical applications, and taking into account the ethical issue associated with the stem cell therapy. Methods We have searched Pubmed/Medline for clinical trials, involving the use of human stem cells, using the key words "stem cells" combined with the key words "transplantation", "pathology", "guidelines", "properties" and "risks". All the relevant clinical trials have been included. The results have been divided into different categories, basing on the way stem cells have been employed in different pathological conditions.Keywords
This publication has 271 references indexed in Scilit:
- Bronchiolitis Obliterans Syndrome After Allogeneic Hematopoietic Stem Cell Transplantation—An Increasingly Recognized Manifestation of Chronic Graft-versus-Host DiseaseTransplantation and Cellular Therapy, 2009
- C-Peptide Levels and Insulin Independence Following Autologous Nonmyeloablative Hematopoietic Stem Cell Transplantation in Newly Diagnosed Type 1 Diabetes MellitusJAMA, 2009
- Parkinson's Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming FactorsCell, 2009
- GVHD: A Continuing Barrier to the Safety of Allogeneic TransplantationTransplantation and Cellular Therapy, 2009
- Guidelines and Techniques for the Generation of Induced Pluripotent Stem CellsCell Stem Cell, 2008
- Timing cell-fate determination during asymmetric cell divisionsCurrent Opinion in Neurobiology, 2008
- Multiple sclerosisThe Lancet, 2008
- Mesenchymal Stem Cells: Revisiting History, Concepts, and AssaysCell Stem Cell, 2008
- Liver cirrhosisThe Lancet, 2008
- The Evolving Concept of a Stem CellCell, 2001