Blood–materials interactions: The minimum interfacial free energy and the optimum polar/apolar ratio hypotheses
- 1 July 1982
- journal article
- research article
- Published by Wiley in Journal of Biomedical Materials Research
- Vol. 16 (4), 381-398
- https://doi.org/10.1002/jbm.820160407
Abstract
Numerous hypotheses exist to explain observed blood–materials interactions. It is the purpose of this article to test two popular hypotheses, namely, the minimum interfacial free energy hypothesis and the optimum polar/apolar ratio hypothesis. Methacrylate polymers and copolymers were characterized using the captive bubble underwater contact angle method; bulk water content was determined by gravimetric methods; streaming potential measurements were made; and surface roughness and possible particulate contamination were evaluated by reflected light microscopy. In vitro blood tests include whole blood clotting time measurements on polymer‐coated tubes; centrifugal force platelet adhesion on polymer‐coated coverslips; and a measure of the partial thromboplastin time, Russell's viper venom time (Stypven time), and the prothrombin time of native whole blood exposed to polymer‐coated microscope slides. Results suggest that platelet adhesion correlates in the opposite direction of whole blood clotting time and partial thromboplastin time, emphasizing the need for a multiparameter approach to blood–materials testing. Based on these tests the minimum interfacial free energy hypothesis is not supported. In fact, the data suggest the opposite to be true. It is apparent that platelet adhesion can be a misleading indicator of blood compatibility. Neither hypotheses can explain the apparent conflict between the platelet adhesion data and the coagulation time data.This publication has 18 references indexed in Scilit:
- Transformation and motility of human platelets: details of the shape change and release reaction observed by optical and electron microscopy.The Journal of cell biology, 1979
- On the Uniformity of Thin Films: A New Technique Applied to PolyimidesJournal of the Electrochemical Society, 1979
- Blood‐compatibility‐water‐content relationships for radiation‐grafted hydrogelsJournal of Polymer Science: Polymer Symposia, 1979
- Surface characterization of poly(hydroxyethyl methacrylate) and related polymers. I. Contact angle methods in waterJournal of Polymer Science: Polymer Symposia, 1979
- Covalently attached organic monolayers on semiconductor surfacesJournal of the American Chemical Society, 1978
- Preparation and properties of stereoregular poly(hydroxyethyl methacrylate) polymers and hydrogelsPolymer, 1978
- A surface energy analysis of bioadhesionPolymer, 1977
- WATER AS A BIOMATERIALASAIO Journal, 1973
- Generalization of Theory for Estimation of Interfacial EnergiesIndustrial & Engineering Chemistry, 1970
- Studies on Platelet Factor-3 AvailabilityBritish Journal of Haematology, 1965