The AcrAB-TolC Pump Is Involved in Macrolide Resistance but Not in Telithromycin Efflux inEnterobacter aerogenesandEscherichia coli
- 1 September 2004
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 48 (9), 3621-4
- https://doi.org/10.1128/aac.48.9.3621-3624.2004
Abstract
The role of the AcrAB-TolC pump in macrolide and ketolide susceptibility in Escherichia coli and Enterobacter aerogenes was studied. Efflux pump inhibitor restored erythromycin, clarithromycin, and telithromycin susceptibilities to multidrug-resistant isolates. No modification of telithromycin accumulation was detected in E. aerogenes acrAB or tolC derivatives compared to that in the parental strain. Two independent efflux pumps, inhibited by phenylalanine arginine beta-naphthylamide, expel macrolides and telithromycin in E. aerogenes.Keywords
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