Plasma secretin and pancreatic bicarbonate response to exogenous secretin in man.
Open Access
- 1 March 1977
- Vol. 18 (3), 191-195
- https://doi.org/10.1136/gut.18.3.191
Abstract
The dose response of duodenal bicarbonate production during synthetic porcine secretin infusions was studied in six healthy volunteers and related to plasma secretin immunoreactivity. Secretin was infused in each individual at four different doses from 0-1 to 2-7 CU/kg/h, each infusion lasting for 60 minutes. Mean maximal bicarbonate secretion was 33 +/- 4 mEq/h. The secretin plasma level for half maximal bicarbonate response was estimated to be 22 pmol/l. As this level is reported to be achieved by intraduodenal acidification in man, it is concluded that secretin may well play a part in the control of duodenal pH.This publication has 33 references indexed in Scilit:
- Effect of vagotomy on secretin release in man.Gut, 1975
- Immunochemical studies of the endocrine cells of the gastrointestinal tract. II An immunoperoxide technique for the localization of secretin containing cells in human duodenum.Journal of Clinical Pathology, 1975
- Failure of secretin release in patients with duodenal ulcer.BMJ, 1975
- The role of secretin in the inhibition of gastric secretion by intraduodenal acidGut, 1974
- Effect of secretin and graded doses of CCK-PZ on pancreatic secretion in manDigestive Diseases and Sciences, 1974
- Effects of Intraduodenal Administration of HCl and Glucose on Circulating Immunoreactive Secretin and Insulin ConcentrationsJCI Insight, 1974
- Studies on the Elimination of Secretin and Cholecystokinin with Regard to the Kinetics of Exocrine Pancreatic SecretionDigestion, 1974
- Progess report. Is secretin secreted?Gut, 1973
- Zur Synthese des Sekretins, VI. Reindarstellung des synthetischen SekretinsEuropean Journal of Inorganic Chemistry, 1972
- On the Biological Activity and Amino Acid Composition of Secretin.Acta Chemica Scandinavica, 1961