Total brain N -acetylaspartate
- 11 January 2000
- journal article
- Published by Ovid Technologies (Wolters Kluwer Health) in Neurology
- Vol. 54 (1), 15
- https://doi.org/10.1212/wnl.54.1.15
Abstract
Objective: To quantitate the extent of neuronal cell loss in MS via the whole brain’s N-acetylaspartate (NAA) concentration (WBNAA). Methods: Because NAA is assumed to be present only in neuronal cell bodies and their axons, we measured WBNAA as a marker for viable neurons in 12 patients (9 women and 3 men, 26 to 53 years of age) suffering from relapsing-remitting (RR) MS for at least 5 years and compared them with 13 age- and sex-matched normal controls. Total brain NAA was determined with proton MR spectroscopy, and WBNAA was obtained by dividing it by the total brain volume, calculated from high resolution MRI. Results: The WBNAA of the RR MS patients was lower than their matched controls (p < 0.005). This difference was greater among older than younger subjects. The linear prediction equations of WBNAA with age indicate a faster, ×10, decline in the patients, ∼0.8% per year of age (p = 0.022). Conclusion: The age-dependent decrease of whole brain N-acetylaspartate (WBNAA) in the patients suggests that progressive neuronal cell loss is a cardinal feature of this disease. WBNAA offers a quick, highly reproducible measure of disease progression and may be an important marker of treatment efficacy in MS as well as other neurodegenerative diseases.Keywords
This publication has 29 references indexed in Scilit:
- Assessment of lesion pathology in multiple sclerosis using quantitative MRI morphometry and magnetic resonance spectroscopyBrain, 1996
- Spinal MRI in patients with suspected multiple sclerosis and negative brain MRIBrain, 1996
- Spinal cord atrophy and disability in multiple sclerosisBrain, 1996
- Investigation into the Role of N‐Acetylaspartate in Cerebral OsmoregulationJournal of Neurochemistry, 1995
- High Resolution Proton NMR Spectroscopy of Multiple Sclerosis LesionsJournal of Neurochemistry, 1995
- Localized in vivo proton spectroscopy in the brain of patients with multiple sclerosisMagnetic Resonance in Medicine, 1991
- Acquisition and quantitation in proton spectroscopyNMR in Biomedicine, 1991
- Human brain proton localized NMR spectroscopy in multiple sclerosisMagnetic Resonance in Medicine, 1991
- Proton magnetic resonance spectroscopy of human brain in vivo in the evaluation of multiple sclerosis: Assessment of the load of diseaseMagnetic Resonance in Medicine, 1990
- Localized proton NMR spectroscopy in different regions of the human brain in vivo. Relaxation times and concentrations of cerebral metabolitesMagnetic Resonance in Medicine, 1989