Control of Haemopoietic Stem Cell Proliferation by Cells in DNA Synthesis

Abstract

For the slowly proliferating population of the hemopoietic pluripotent stem cells (CFUs), the response after damage by hydroxyurea to cells synthesizing DNA differed from that after damage by colchicine to cells entering mitosis. The killing of DNA synthesizing cells [mouse] elicited increased proliferation in the CFUs population. Apparently, cells in the S phase may inhibit the entry of nonproliferating G0 cells into the cell cycle and in this way control cellular proliferation.