Insight into E-selectin/ligand interaction from the crystal structure and mutagenesis of the lec/EGF domains
- 1 February 1994
- journal article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 367 (6463), 532-538
- https://doi.org/10.1038/367532a0
Abstract
The three-dimensional structure of the ligand-binding region of human E-selectin has been determined at 2.0 A resolution. The structure reveals limited contact between the two domains and a coordination of Ca2+ not predicted from other C-type lectins. Structure/function analysis indicates a defined region and specific amino-acid side chains that may be involved in ligand binding. These features of the E-selectin/ligand interaction have important implications for understanding the recruitment of leukocytes to sites of inflammation.Keywords
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