CHEK2 contribution to hereditary breast cancer in non-BRCAfamilies
Open Access
- 24 November 2011
- journal article
- research article
- Published by Springer Science and Business Media LLC in Breast Cancer Research
- Vol. 13 (6), R119
- https://doi.org/10.1186/bcr3062
Abstract
Mutations in the BRCA1 and BRCA2 genes are responsible for only a part of hereditary breast cancer (HBC). The origins of "non-BRCA" HBC in families may be attributed in part to rare mutations in genes conferring moderate risk, such as CHEK2, which encodes for an upstream regulator of BRCA1. Previous studies have demonstrated an association between CHEK2 founder mutations and non-BRCA HBC. However, very few data on the entire coding sequence of this gene are available.Keywords
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