Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes

Abstract

Joop Jansen and colleagues report the identification of somatic mutations altering the histone methyltransferase EZH2 in myelodysplastic syndromes. They find EZH2 deletions, missense and frameshift mutations in about 23% of myelodysplastic syndrome samples.