Interruption of Transmission of Onchocerca volvulus in the Oaxaca Focus, Mexico
- 1 July 2010
- journal article
- Published by American Society of Tropical Medicine and Hygiene in The American Journal of Tropical Medicine and Hygiene
- Vol. 83 (1), 21-27
- https://doi.org/10.4269/ajtmh.2010.09-0544
Abstract
All endemic communities of the Oaxaca focus of onchocerciasis in southern Mexico have been treated annually or semi-annually with ivermectin since 1994. In-depth epidemiologic assessments were performed in communities during 2007 and 2008. None of the 52,632 Simulium ochraceum s.l. collected in four sentinel communities was found to contain parasite DNA when tested by polymerase chain reaction-enzyme-linked immunosorbent assay (PCR-ELISA), resulting in an upper bound of the infection rate in the vectors of 0.07/2,000. The prevalence of microfilariae (mf) in the cornea and/or anterior chamber of the eye was also zero (0 of 1,039 residents examined; 95%-UL = 0.35%). Similarly, all 1,164 individuals examined by skin biopsy were mf negative (95%-UL = 0.31%), and sera collected from 3,569 children from 25 communities did not harbor Ov16 IgG4-antibodies (95%-UL = 0.09%). These meet the criteria for absence of morbidity and parasite transmission in the Oaxaca focus. As a result mass treatments with ivermectin were halted in 2009.Keywords
This publication has 24 references indexed in Scilit:
- Lack of Active Onchocerca volvulus Transmission in the Northern Chiapas Focus of MexicoThe American Journal of Tropical Medicine and Hygiene, 2010
- Successful Interruption of Transmission of Onchocerca volvulus in the Escuintla-Guatemala Focus, GuatemalaPLoS Neglected Tropical Diseases, 2009
- Impact of long-term treatment of onchocerciasis with ivermectin in Ecuador: potential for elimination of infectionBMC Medicine, 2007
- Field Applicability of a Rapid‐Format Anti–Ov‐16 Antibody Test for the Assessment of Onchocerciasis Control Measures in Regions of EndemicityThe Journal of Infectious Diseases, 2006
- A Rapid‐Format Antibody Card Test for Diagnosis of OnchocerciasisThe Journal of Infectious Diseases, 2000
- Onchocerciasis: changes in Mexico in transmissionPathogens and Global Health, 1998
- Determining the Prevalence of Onchocerca volvulus Infection in Vector Populations by Polymerase Chain Reaction Screening of Pools of Black FliesThe Journal of Infectious Diseases, 1995
- An Immunogenic Onchocerca volvulus Antigen: a Specific and Early Marker of InfectionScience, 1991
- Standardization of criteria for assessing the effect of Simulium control in onchocerciasis control programmesTransactions of the Royal Society of Tropical Medicine and Hygiene, 1978
- THE USE OF LOGARITHMS IN THE INTERPRETATION OF CERTAIN ENTOMOLOGICAL PROBLEMSAnnals of Applied Biology, 1937